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Cytokine receptor-mediated trafficking of preformed IL-4 in eosinophils identifies an innate immune mechanism of cytokine secretion
(National Academy of Sciences, 2020)
Rab Proteins: Insights into Intracellular Trafficking in Endometrium
(SAGE Publications, 2020-07)
Rab proteins belong to the Ras superfamily of small monomeric GTPases. These G proteins are the main controllers of vesicular transport in every tissue, among them, the endometrium. They are in charge of to the functional ...
Rab GTPases and the Autophagy Pathway: Bacterial Targets for a Suitable Biogenesis and Trafficking of Their Own Vacuoles
(MDPI, 2016-03)
Autophagy is an intracellular process that comprises degradation of damaged organelles, protein aggregates and intracellular pathogens, having an important role in controlling the fate of invading microorganisms. Intracellular ...
Mecanismos de secreção de eosinófilos: compartimentalização e tráfego vesicular de sintaxina-17, CD63 e interferon-gama
(Universidade Federal de Minas GeraisBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASPrograma de Pós-Graduação em Biologia CelularUFMG, 2018-11-28)
Eosinophils are able to release numerous mediators that are pre-synthesized
and stored within their cytoplasmic specific (secretory) granules. Secretion can occur
by: (i) piecemeal degranulation (PMD), characterized by ...
Omp25-dependent engagement of SLAMF1 by Brucella abortus in dendritic cells limits acute inflammation and favours bacterial persistence in vivo
(Wiley Blackwell Publishing, Inc, 2020-01)
The strategies by which intracellular pathogenic bacteria manipulate innate immunity to establish chronicity are poorly understood. Here, we show that Brucella abortus outer membrane protein Omp25 specifically binds the ...
Estudios de secreción de IL-12 en macrófagos J774A.1
(2012)
El tráfico de membranas en macrófagos activados es requerido para dos eventos críticos en la inmunidad innata, como son fagocitosis y secreción de citoquinas proinflamatorias. Sin embargo, no existe evidencia significativa ...
Caveolin-mediated endocytosis of the Chlamydia M278 outer membrane peptide encapsulated in poly(lactic acid)-Poly(ethylene glycol) nanoparticles by mouse primary dendritic cells enhances specific immune effectors mediated by MHC class II and CD4+ T cells
(Elsevier, 2018-03)
We previously developed a Chlamydia trachomatis nanovaccine (PPM) by encapsulating a chlamydial M278 peptide within poly(lactic acid)-poly(ethylene glycol) biodegradable nanoparticles that immunopotentiated Chlamydia-specific ...
Controlling protein interactions in blood for effective liver immunosuppressive therapy by silica nanocapsules
(Royal Society of Chemistry, 2020-01)
Immunosuppression with glucocorticoids is a common treatment for autoimmune liver diseases and after liver transplant, which is however associated with severe side-effects. Targeted delivery of glucocorticoids to inflammatory ...
Male genital tract immune response against Chlamydia trachomatis infection
(BioScientifica, 2017-07-11)
Chlamydia trachomatis is the most commonly reported agent of sexually transmitted bacterial infections worldwide. This pathogenfrequently leads to persistent, long-term, subclinical infections, which in turn may cause ...