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Inhibition of thimet oligopeptidase by siRNA alters specific intracellular peptides and potentiates isoproterenol signal transduction
(ELSEVIER SCIENCE BVAMSTERDAM, 2012)
Mammalian cells have a large number of intracellular peptides that are generated by extralysosomal proteases. In this study, the enzymatic activity of thimet oligopeptidase (EP24.15) was inhibited in human embryonic kidney ...
Natural intracellular peptides can modulate the interactions of mouse brain proteins and thimet oligopeptidase with 14-3-3e and calmodulin
(WILEY-BLACKWELLHOBOKEN, 2012)
Protein interactions are crucial for most cellular process. Thus, rationally designed peptides that act as competitive assembly inhibitors of protein interactions by mimicking specific, determined structural elements have ...
Characterization of Intracellular Peptides from Zebrafish (Danio rerio) Brain
(Mary Ann Liebert, Inc, 2019-04-24)
Peptides represent a large class of cell signaling molecules, and they are mainly produced by the classical secretory pathway or during protein degradation. The peptide profile of Danio rerio (zebrafish) shows a lack of ...
Intracellular peptides as natural regulators of cell signaling
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2008)
Protein degradation by the ubiquitin proteasome system releases large amounts of oligopeptides within cells. To investigate possible functions for these intracellularly generated oligopeptides, we fused them to a cationic ...