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Paneth and Intestinal Stem Cells Preserve their Functional Integrity during Worsening of Acute Cellular Rejection in Small Bowel Transplantation
(Wiley Blackwell Publishing, Inc, 2017-11)
Graft survival after small bowel transplantation remains impaired due to acute cellular rejection (ACR), the leading cause of graft loss. Although it was shown that the number of enteroendocrine progenitor cells in intestinal ...
Adaptive physiological and morphological adjustments mediated by intestinal stem cells in response to food availability in mice
(Frontiers Media S.A., 2019)
Copyright © 2019 Peña-Villalobos, Casanova-Maldonado, Lois, Sabat and Palma.Several studies have evaluated plastic changes in the morphology of the digestive tract in rodents subjected to caloric restriction or restricted ...
Vitamin D is a determinant of mouse intestinal Lgr5 stem cell functions
(Oxford University Press, 2015-01)
Lgr5+ intestinal crypt base columnar cells function as stem cells whose progeny populate the villi, and Lgr5+ cells in which Apc is inactivated can give rise to tumors. Surprisingly, these Lgr5+ stem cell properties were ...
Diversity of fate outcomes in cell pairs under lateral inhibition
(Company of Biologists, 2017-04)
Cell fate determination by lateral inhibition via Notch/Delta signalling has been extensively studied. Most formalised models consider Notch/Delta interactions in fields of cells, with parameters that typically lead to ...
Paneth cells and their multiple functions
(2022-01-01)
The small intestine mucosa is lined by specialized cells that form the crypt-villus axis, which expands its surface. Among the six intestinal epithelial cell types, the Paneth cell is located at the base of the crypt, and ...
Cell therapy in experimental model of inflammatory bowel disease
(Sociedade Brasileira de Coloproctologia, 2015-03-01)
Inflammatory bowel disease, which mainly involves Crohn's disease and ulcerative rectocolitis, is an inflammatory condition of the mucosa that can afflict any segment of the gastrointestinal tract. Despite the fact that ...
Cell therapy in experimental model of inflammatory bowel diseaseTerapia celular em modelo experimental de doença inflamatória intestinal
(Sociedade Brasileira de Coloproctologia, 2015)