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Differences between nuclear run-off and mRNA levels for multidrug resistance gene expression in the cephalocaudal axis of the mouse Intestine
(ELSEVIER SCIENCE BV, 1995)
P-glycoprotein is a multidrug transporter encoded by the mdr3 gene in the mouse intestinal epithelium. The aims of this study were to characterize the mdr3 gene expression in the cephalocaudal axis of the intestine in adult ...
Fructose-induced metabolic syndrome decreases protein expression and activity of intestinal P-glycoprotein
(Elsevier Inc, 2015-01)
Objectves: Metabolic syndrome (MetS) is a health disorder that increases the risk for cardiovascular complications such as heart disease and type 2 diabetes. Some drugs used in patients with MetS are substrates of intestinal ...
P-glycoprotein in sheep liver and small intestine: gene expression and transport efflux activity.
(Wiley-blackwell Publishing, Inc, 2013-12)
The role of the transporter P-glycoprotein (P-gp) in the disposition kinetics of different drugs therapeutically used in veterinary medicine has been demonstrated. Considering the anatomo-physiological features of the ...
Acetaminophen Inhibits Intestinal P-Glycoprotein Transport Activity
(Wiley, 2013-10)
Repeated acetaminophen (AP) administration modulates intestinal P-glycoprotein (P-gp) expression. Whether AP can modulate P-gp activity in a short-term fashion is unknown. We investigated the acute effect of AP on rat ...
A novel approach in mucoadhesive drug delivery system to improve zidovudine intestinal permeability
(2016-10-01)
Zidovudine (AZT) mucoadhesive solid dispersions (SD) were prepared using a sodium starch glycolate (SSG) and hypromellose phthalate (HPMCP) mixtures as carrier to enhance the intestinal permeability and bioavailability of ...
ABC transporters in extrahepatic tissues: Pharmacological regulation in heart and intestine
(Bentham Science Publishers, 2019-01)
ATP binding cassette (ABC) transporters are transmembrane proteins expressed in secretory epithelia like the liver, kidneys and intestine, in the epithelia exhibiting barrier function such as the blood-brain barrier and ...
Modulation of the P-glycoprotein-mediated intestinal secretion of ivermectin: in vitro and in vivo assessments
(American Society for Pharmacology and Experimental Therapeutics, 2006-03)
The everted gut sac method was used to assess the role of the P-glycoprotein (P-gp) on the intestinal secretion of ivermectin (IVM), an antiparasitic widely used in human and veterinary medicine. The work included the ...
Involvement of P-glycoprotein on ivermectin kinetic behaviour in sheep: itraconazole-mediated changes on gastrointestinal disposition
(Wiley Blackwell Publishing, Inc, 2007-06)
Different pharmacological approaches have been used in an attempt to increased drug systemic availability of anthelmintic drugs. The comparative effect of the itraconazole (ITZ)-mediated modulation of P-glycoprotein (P-gp) ...
Acid diterpenes from Copaiba oleoresin (Copaifera langsdorffii): Chemical and plasma stability and intestinal permeability using Caco-2 cells
(2019-05-10)
Ethnopharmacological relevance: Copaiba oleoresin has been used in folk medicine in the treatment of bronchitis, syphilis, skin diseases and ulcers due to its anti-inflammatory and antiseptic activities, but there is no ...