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Molecular characterization of IPNV RNA replication intermediates during the viral infective cycle
(2009)
Infectious Pancreatic Necrosis Virus (IPNV) is a bisegmented, double-stranded RNA virus, which belongs to the Birnaviridae family. In the current study, we have analyzed the RNA replication intermediates (RI) purified ...
The Essential, Ubiquitous Single-Stranded DNA-Binding Proteins
(2021-01-01)
Maintenance of genomes is fundamental for all living organisms. The diverse processes related to genome maintenance entail the management of various intermediate structures, which may be deleterious if unresolved. The most ...
Mus81-Eme1-dependent aberrant processing of DNA replication intermediates in mitosis impairs genome integrity
(Science Advances is the American Association for the Advancement of Science, 2020-12)
Chromosome instability (CIN) underpins cancer evolution and is associated with drug resistance and poor prognosis. Understanding the mechanistic basis of CIN is thus a priority. The structure-specific endonuclease Mus81-Eme1 ...
Structural rearrangements in the mitochondrial genome of Drosophila melanogaster induced by elevated levels of the replicative DNA helicase
(Oxford Univ Press, 2018-04-06)
Pathological conditions impairing functions of mitochondria often lead to compensatory upregulation of the mitochondrial DNA (mtDNA) replisome machinery, and the replicative DNA helicase appears to be a key factor in ...
FBH1 mediates DNA double strand breakage and apoptosis in response to DNA replication stress
(Rockefeller Univ Press, 2013-01)
Proper resolution of stalled replication forks is essential for genome stability. Purification of FBH1, a UvrD DNA helicase, identified a physical interaction with replication protein A (RPA), the major cellular singlestranded ...