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Treatment of multiple sclerosis with interferons Tratamiento de la esclerosis multiple con interferones
(1996)
Despite the important achievements in clinical and experimental aspects of demylinatlng diseases and multiple sclerosis (MS), its pathogenesis still remains unknown. The most commonly held view is that it is an autoimmune ...
Interferon-Β lipofection II: Mechanisms involved in cell death and bystander effect induced by cationic lipid-mediated interferon-Β gene transfer to human tumor cells
(Nature Publishing Group, 2012-06)
We evaluated the cytotoxic effects (apoptosis, necrosis and early senescence) of human interferon-B (hIFNB) gene lipofection. The cytotoxicity of hIFNB gene lipofection resulted equivalent to that of the corresponding ...
Therapeutic potential of bleomycin plus suicide or interferon-β gene transfer combination for spontaneous feline and canine melanoma
(Impact Journals, 2017-12)
We originated and characterized melanoma cell lines derived from tumors of two feline and two canine veterinary patients. These lines reestablished the morphology, physiology and cell heterogeneity of their respective ...
Bortezomib enhances the antitumor effects of interferon-β gene transfer on melanoma cells
(Bentham Science Publishers, 2017-05)
We evaluated the cytotoxic effects of the combination of bortezomib (BTZ) and interferon-β (IFNβ) gene lipofection on cultured melanoma cells. Four canine mucosal (Ak, Br, Bk and Ol) and two human dermal (A375 and SB2) ...
Multiplexed Gene Expression as a Characterization of Bioactivity for Interferon Beta (IFN-β) Biosimilar Candidates: Impact of Innate Immune Response Modulating Impurities (IIRMIs)
(Springer, 2019)
Recombinant human interferon-β (rhIFN-β) therapy is the first-line treatment in relapsing-remitting forms of multiple sclerosis (MS). The mechanism of action underlying its therapeutic activity is only partially understood ...
Metodologias iniciais para implementação de um ELISA para detecção do interferon beta humano recombinante (1A) com aplicação no controle de qualidade de Bio-Manguinhos
(Instituto de Tecnologia em Imunobiológicos., 2012)
Mechanisms enhancing the cytotoxic effects of bleomycin plus suicide or interferon-β gene lipofection in metastatic human melanoma cells
(Bentham Science Publishers, 2018-05)
Background: Three metastatic human melanoma cell lines generated from patient removed lymph nodes and spleen metastasis were established in our laboratory. Objective: To investigate the mechanisms enhancing the cytotoxic ...
Superprodução do interferon β1 humano recombinante em Escherichia coli
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2008)
Interferons are proteins expressed by different human cells and synthesized in response to many chemical and biological agents. They are involved in antiviral, antiproliferative and immunomodulatory responses, acting to ...
Superprodução do interferon β1 humano recombinante em Escherichia coli
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2008)
Interferons are proteins expressed by different human cells and synthesized in response to many chemical and biological agents. They are involved in antiviral, antiproliferative and immunomodulatory responses, acting to ...
Human interferon B1 ser17: Coding DNA synthesis, expression, purification and characterization of bioactive recombinant protein
(2010-09-01)
A protocol to produce large amounts of bioactive homogeneous human interferon β1 expressed in Escherichia coli was developed. Human interferon β1 ser17 gene was constructed, cloned and subcloned, and the recombinant protein ...