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The Netrin-1-Neogenin-1 signaling axis controls neuroblastoma cell migration via integrin-beta 1 and focal adhesion kinase activation
(Taylor & Francis, 2021)
Neuroblastoma is a highly metastatic tumor that emerges from neural crest cell progenitors. Focal
Adhesion Kinase (FAK) is a regulator of cell migration that binds to the receptor Neogenin-1 and is
upregulated in ...
Association of α v β 3 integrin expression with the metastatic potential and migratory and chemotactic ability of human osteosarcoma cells
(Springer, 2005-12)
INTRODUCTION: Expression of adhesion molecules such as alphavbeta3 integrin has been associated with the metastatic potential of tumor cells. The purpose of this study was to determine whether alphavbeta3 expression ...
Role of glycosylation in hypoxia-driven cell migration and invasion
(NLM (Medline), 2019)
Hypoxia, a common condition of the tumor microenvironment, induces changes in the proteome of cancer cells, mainly via HIF-1, a transcription factor conformed by a constitutively expressed β-subunit and an oxygen-regulated ...
RAP1-RAC1 Signaling Has an Important Role in Adhesion and Migration in HNSCC
(2020-07-01)
Cell-cell adhesion is a key mechanism to control tissue integrity and migration. In head and neck squamous cell carcinoma (HNSCC), cell migration facilitates distant metastases and is correlated with poor prognosis. RAP1, ...
RECK-mediated β1-integrin regulation by TGF-β1 is critical for wound contraction in mice
(2015-08-06)
Fibroblasts are critical for wound contraction; a pivotal step in wound healing. They produce and modify the extracellular matrix (ECM) required for the proper tissue remodeling. Reversion- inducing cysteine-rich protein ...
Estudo dos efeitos antiangiogênicos da desintegrina-símile Alternagina-C (ALT-C) em células endoteliais (HUVEC), tendo como alvo a integrina α2β1
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Genética Evolutiva e Biologia Molecular - PPGGEvCâmpus São Carlos, 2020-03-04)
Angiogenesis is a crucial process in tumor progression, and it is mainly regulated by the vascular endothelial growth factor (VEGF) and its receptor, VEGFR2. Studies have shown that VEGF/VEGFR2 axis signaling is directly ...
Granulocyte colony-stimulating factor (G-CSF) upregulates β1 integrin and increases migration of human trophoblast Swan 71 cells via PI3K and MAPK activation
(Elsevier, 2016)
Abstract: Multiple cytokines and growth factors expressed at the fetal-maternal interface are involved in the regulation of trophoblast functions and placental growth, but the role of G-CSF has not been completely established. ...
Thy-1 (CD90)-induced metastatic cancer cell migration and invasion are β3 integrin-dependent and involve a Ca2+/P2X7 receptor signaling axis
(Frontiers Media, 2021)
Cancer cell adhesion to the vascular endothelium is an important step in tumor
metastasis. Thy-1 (CD90), a cell adhesion molecule expressed in activated endothelial
cells, has been implicated in melanoma metastasis by ...
A Penicillin Derivative Exerts an Anti-Metastatic Activity in Melanoma Cells Through the Downregulation of Integrin αvβ3 and Wnt/β-Catenin Pathway
(Frontiers Media, 2020-02)
The synthetic triazolylpeptidyl penicillin derivative, named TAP7f, has been previously characterized as an effective antitumor agent in vitro and in vivo against B16-F0 melanoma cells. In this study, we investigated the ...
A collagen IV-derived peptide disrupts α5β1 integrin and potentiates Ang2/Tie2 signaling
(NLM (Medline), 2019-02)
The angiopoietin (Ang)/Tie2 signaling pathway is essential for maintaining vascular homeostasis, and its dysregulation is associated with several diseases. Interactions between Tie2 and α5 β1 integrin have emerged as part ...