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In silico development of a scFv antagonistic to α4β1 integrin
(Fiocruz/Instituto de Tecnologia em Imunobiológicos, 2018)
Expression of α6 integrin subunit in bovine oocyte and its potential role during fertilization
(Scientific Research, 2013)
Fertilization in mammals requires the successful completion of a sequence of steps, starting with the transport of gametes in the reproductive tract and ending with sperm-egg membrane fusion to produce a zygote. Although ...
Recruitment of integrin α ν β 3 to integrin α 5 β 1 -induced clusters enables focal adhesion maturation and cell spreading
(Company of Biologists, 2019-11)
The major fibronectin (FN)-binding α5β1 and αvβ3 integrins exhibit cooperativity during cell adhesion, migration and mechanosensing, through mechanisms that are not yet fully resolved. Exploiting mechanically tunable ...
Expression of α6 integrin subunit in bovine oocyte and its potential role during fertilization
(Scientific Research, 2016)
Expression of α6 integrin subunit in bovine oocyte and its potential role during fertilization
(Scientific Research, 2016)
Chronic stress induces upregulation of brain-derived neurotrophic factor (BDNF) mRNA and integrin α5 expression in the rat pineal gland
(2006)
Chronic stress affects brain areas involved in learning and emotional responses. These alterations have been related with the development of cognitive deficits in major depression. Moreover, stress induces deleterious ...
Generation of a scFv antagonistic to VLA-4 integrin as potential therapeutic target in muscular dystrophies: in silico phase
(Fiocruz/Instituto de Tecnologia em Imunobiológicos, 2018)
AhR ligand aminoflavone suppresses α6-integrin–Src–Akt signaling to attenuate tamoxifen resistance in breast cancer cells
(Wiley-liss, Div John Wiley & Sons Inc, 2018-01)
More than 40% of patients with luminal breast cancer treated with endocrine therapy agent tamoxifen demonstrate resistance. Emerging evidence suggests tumor initiating cells (TICs) and aberrant activation of Src and Akt ...
Substrate engagement of integrins α5 β1 and αv β3 is necessary, but not sufficient, for high directional persistence in migration on fibronectin
(Nature Publishing Group, 2016-03)
The interplay between specific integrin-mediated matrix adhesion and directional persistence in cell migration is not well understood. Here, we characterized fibroblast adhesion and migration on the extracellular matrix ...