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Familial hemiplegic migraine type-1 mutated cav2.1 calcium channels alter inhibitory and excitatory synaptic transmission in the lateral superior olive of mice
(Elsevier Science, 2015-01)
CaV2.1 Ca2+ channels play a key role in triggering neurotransmitter release and mediating synaptic transmission. Familial hemiplegic migraine type-1 (FHM-1) is caused by missense mutations in the CACNA1A gene that encodes ...
Effects of ethanol on glycinergic synaptic currents in mouse spinal cord neurons
(American Physiological Society, 2014)
Ethanol increased the frequency of miniature glycinergic currents [miniature inhibitory postsynaptic currents (mIPSCs)] in cultured spinal neurons. This effect was dependent on intracellular calcium augmentation, since ...
Growth hormone secretagogue receptor constitutive activity impairs voltage-gated calcium channel-dependent inhibitory neurotransmission in hippocampal neurons
(Wiley Blackwell Publishing, Inc, 2018-11)
Key points: Presynaptic CaV2 voltage-gated calcium channels link action potentials arriving at the presynaptic terminal to neurotransmitter release. Hence, their regulation is essential to fine tune brain circuitry. CaV2 ...
Short-term effects of pilocarpine on rat hippocampal neurons in culture
(Blackwell Publishing Inc, 2002-01-01)
Purpose: Status epilepticus (SE) has been considered an epileptogenic factor in humans. in the pilocarpine (PILO) model, after a brief period marked by SE, the rats exhibit recurrent spontaneous seizures, mimicking the ...
Wnt-5a Modulates Recycling of Functional GABAA Receptors on Hippocampal Neurons
(2010-06-23)
GABAA receptors (GABAA-Rs) play a significant role in mediating fast synaptic inhibition and it is the main inhibitory receptor in the
CNS. The role of Wnt signaling in coordinating synapse structure and function in the ...
Transplant of GABAergic Precursors Restores Hippocampal Inhibitory Function in a Mouse Model of Seizure Susceptibility
(Cognizant Communication Corp, 2010-01-01)
Defects in GABAergic function can cause epilepsy. in the last years, cell-based therapies have attempted to correct these defects with disparate success on animal models of epilepsy. Recently, we demonstrated that medial ...
Short-term synaptic plasticity regulates the level of olivocochlear inhibition to auditory hair cells
(Society for Neuroscience, 2011-10)
In the mammalian inner ear, the gain control of auditory inputs is exerted by medial olivocochlear (MOC) neurons that innervate cochlear outer hair cells (OHCs). OHCs mechanically amplify the incoming sound waves by virtue ...
Enhanced hair cell postsynaptic responses alter release from presynaptic efferent neurons to prolong inhibition of the cochlea
(Association for Research in Otolaryngology, 2018)
Gain control of the auditory system operates at multiple levels. Cholinergic medial olivocochlear (MOC) fibers that originate in the brainstem and make direct synaptic contacts at the base of the outer hair cells (OHCs) ...
Modulation of gaba release from the thalamic reticular nucleus by cocaine and caffeine: role of serotonin receptors
(Wiley, 2015-10)
Serotonin receptors are targets of drug therapies for a variety of neuropsychiatric and neurodegenerative disorders. Cocaine inhibits the re-uptake of serotonin (5-HT), dopamine, and noradrenaline, whereas caffeine blocks ...
Grafting of GABAergic precursors rescues deficits in hippocampal inhibition
(Wiley-Blackwell, 2010-01-01)
P>gamma-Aminobutyric acid (GABA) has an important role in the mechanism of epilepsy. Cell grafts from different sources have been performed to modulate local circuits or increase GABAergic inhibition in animal models of ...