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Targeting polyamine transport in Trypanosoma cruzi
(Elsevier France-editions Scientifiques Medicales Elsevier, 2018-03)
Polyamines play critical roles as regulators of cell growth and differentiation. In contrast with other protozoa, the human parasite Trypanosoma cruzi, the etiological agent of Chagas disease, is auxotrophic for polyamines. ...
Polyamines prevent DFMO-mediated inhibition of angiogenesis
(Elsevier, 1994-04-24)
Tumor growth mainly depend on formation of new blood vessels. DFMO (α-difluoromethylornithine), an inhibitor of polyamine biosynthesis, inhibits tumor growth in many animal tumors. Our investigation was to evaluate the ...
Identification of Trypanosoma cruzi Polyamine Transport Inhibitors by Computational Drug Repurposing
(Frontiers Research Foundation, 2019-10)
Trypanosoma cruzi is the causative agent of Chagas disease, a parasitic infection endemic in Latin America. In T. cruzi the transport of polyamines is essential because this organism is unable to synthesize these compounds ...
Pentamidine exerts in vitro and in vivo anti Trypanosoma cruzi activity and inhibits the polyamine transport in Trypanosoma cruzi
(Elsevier, 2014)
Pentamidine is an antiprotozoal and fungicide drug used in the treatment of leishmaniasis and African trypanosomiasis. Despite its extensive use as antiparasitic drug, little evidence exists about the effect of pentamidine ...
Polyamines and inhibitors used in successive culture media for in vitro rooting in Berberis buxifolia
(Royal Society of New Zealand, 2005-12)
Although Berberis buxifolia has been reported to propagate in vitro, rooting is difficult to achieve during subcultures, with reduced quantity and quality of roots, as is the case with many other woody species. Several ...
Regulation by the exogenous polyamine spermidine of Na,K-ATPase activity from the gills of the euryhaline swimming crab Callinectes danae (Brachyura, Portunidae)
(ELSEVIER SCIENCE INC, 2008)
Euryhaline crustaceans rarely hyporegulates and employ the driving force of the Na,K-ATPase, located at the basal surface of the gill epithelium, to maintain their hemolymph osmolality within a range compatible with cell ...
Polyamine depletion inhibits the autophagic response modulating Trypanosoma cruzi infectivity
(Taylor & Francis, 2013-07)
Autophagy is a cell process that in normal conditions serves to recycle cytoplasmic components and aged or damaged organelles. The autophagic pathway has been implicated in many physiological and pathological situations, ...
PHOTOREACTIONS OF RIBOFLAVIN WITH SPERMINE AND THEIR ROLE IN TRYPTOPHAN PHOTOCONSUMPTION INDUCED BY RIBOFLAVIN
(ELSEVIER SCIENCE SA, 1993)
The influence of spermine (Spr) on riboflavin (Rb) and riboflavin-tryptophan (Rb-Trp) solutions irradiated at 450 nm under aerobic and anaerobic conditions was studied. In both systems, it is shown that Spr interacts with ...