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Whole Blood Mycobacterial Growth Assays for Assessing Human Tuberculosis Susceptibility: A Systematic Review and Meta-Analysis
(Frontiers Media, 2021)
BACKGROUND: Whole blood mycobacterial growth assays (WBMGA) quantify mycobacterial growth in fresh blood samples and may have potential for assessing tuberculosis vaccines and identifying individuals at risk of tuberculosis. ...
Novel inhibitors of the main protease enzyme of SARS-CoV-2 identified via molecular dynamics simulation-guided in vitro assay
(2021-06-01)
For the COVID-19 pandemic caused by SARS-CoV-2, there are currently no effective drugs or vaccines to treat this coronavirus infection. In this study, we focus on the main protease enzyme of SARS-CoV-2, 3CLpro, which is ...
In vitro inhibition of acetylcholinesterase and monoamine oxidase by Syzygium cumini leaves extract and preliminary assessment in animal models
(2022-05-01)
Syzygium cumini (Myrtaceae) is a tropical tree used in traditional medicines to treat several diseases. All parts of S. cumini are used for medicinal purposes and present antioxidant potential. In this study, we evaluated ...
DNA Inhibits the Catalytic Activity of the α Subunit of Protein Kinase CK2
(1995)
The recombinant α subunit of protein kinase CK2 (casein kinase 2) from Xenopus laevis is inhibited by the addition of single stranded or double stranded DNA. This inhibition is competitive with the casein substrate, having ...
Study of Coumarin-Resveratrol Hybrids as Potent Antioxidant Compounds
(MDPI AG, 2015)
In the present work we synthesized a selected series of hydroxylated
3-phenylcoumarins 5–8, with the aim of evaluating in detail their antioxidant properties.
From an in depth study of the antioxidant capacity data ...
Ecotoxicologicaltoolsforthetropics:Sublethalassayswithfishtoevaluate edge-of-fieldpesticiderunofftoxicity
(2010)
This study proposes short-term sublethal assays for the tropics using the fish Poecilia reticulata. Assays were evaluated under realistic exposure scenarios by simulating a runoff over an agricultural area sprayed with ...
Assessment of the chemopreventive effect of casearin B, a clerodane diterpene extracted from Casearia sylvestris (Salicaceae)
(2013-03-01)
Studies have shown that Casearia sylvestris compounds protect DNA from damage both in vitro and in vivo. Complementarily, the aim of the present study was to assess the chemopreventive effect of casearin B (CASB) against ...
Assessment of the chemopreventive effect of casearin B, a clerodane diterpene extracted from Casearia sylvestris (Salicaceae)
(2013-03-01)
Studies have shown that Casearia sylvestris compounds protect DNA from damage both in vitro and in vivo. Complementarily, the aim of the present study was to assess the chemopreventive effect of casearin B (CASB) against ...
Pump-Free Microfluidic Rapid Mixer Combined with a Paper-Based Channel
(2020-07-24)
Capillary forces are commonly employed to transport fluids in pump-free microfluidic platforms such as paper-based microfluidics. However, since paper is a porous material consisting of nonuniform cellulose fibers, it has ...