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Tyrosine phosphorylation is increased in the rat hippocampus during the status epilepticus induced by pilocarpine
(Elsevier B.V., 1998-09-01)
Phosphorylation of tyrosine residue in proteins is an important modulatory process for membrane transduction and cell signaling and for several cellular functions. the concentration and distribution of phosphotyrosine ...
Comparative neuroanatomical and temporal characterization of FluoroJade-positive neurodegeneration after status epilepticus induced by systemic and intrahippocampal pilocarpine in Wistar rats
(ELSEVIER SCIENCE BV, 2011)
The aims of this study were to characterize the spatial distribution of neurodegeneration after status epilepticus (SE) induced by either systemic (S) or intrahippocampal (H) injection of pilocarpine (PILO), two models of ...
Consequences of pilocarpine-induced status epilepticus in immunodeficient mice
(ELSEVIER SCIENCE BVAMSTERDAM, 2013-08-02)
Systemic injection of pilocarpine in rodents induces status epilepticus (SE) and reproduces the main characteristics of temporal lobe epilepsy (TLE). Different mechanisms are activated by SE contributing to cell death and ...
Absence-like seizures in adult rats following pilocarpine-induced status epilepticus early in life
(Associação Brasileira de Divulgação Científica, 2003-12-01)
Administration of pilocarpine causes epilepsy in rats if status epilepticus (SE) is induced at an early age. To determine in detail the electrophysiological patterns of the epileptogenic activity in these animals, 46 Wistar ...
Neuroprotective Effects of Diazepam, Carbamazepine, Phenytoin and Ketamine after Pilocarpine-induced Status Epilepticus
(WILEY-BLACKWELL PUBLISHING, INC, 2009)
Cell damage and spatial localization deficits are often reported as long-term consequences of pilocarpine-induced status epilepticus. In this study, we investigated the neuroprotective effects of repeated drug administration ...
Myocyte-specific enhancer binding factor 2C (MEF2C) expression in the dentate gyrus during development and after pilocarpine-induced status epilepticus: a preliminary report
(Academia Brasileira de Neurologia - ABNEURO, 2008-01-01)
OBJECTIVE: As axon outgrowth and dentate granule cell neurogenesis are hallmarks of hippocampal development and are also the two morphologic changes in the structure of the dentate gyrus after status epilepticus (SE), we ...
Reactive oxygen species generated by NADPH oxidase are involved in neurodegeneration in the pilocarpine model of temporal lobe epilepsy
(ELSEVIER IRELAND LTD, 2010)
Reactive oxygen species (ROS) appear to be involved in several neurodegenerative disorders. We tested the hypothesis that oxidative stress could have a role in the hippocampal neurodegeneration observed in temporal lobe ...
Effect of glycemic state in rats submitted to status epilepticus during development
(Academia Brasileira de Neurologia - ABNEURO, 2006-06-01)
The effect of glycemic state on status epilepticus (SE) development was studied in animals of different ages, submitted to pilocarpine model of epilepsy. Groups: I- Rats with 9-day-old (P9): IA. Submitted to 1SE; IB. ...
Nestin down-regulation of cortical radial glia is delayed in rats submitted to recurrent status epilepticus during early postnatal life
(Academia Brasileira de Neurologia - ABNEURO, 2009-09-01)
OBJECTIVE: Nestin is temporarily expressed in several tissues during development and it is replaced by other protein types during cell differentiation process. This unique property allows distinguishing between undifferentiated ...