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The metabolic and toxicological considerations for immunosuppressive drugs used during pancreas transplantation
(Informa Healthcare, 2012-12-01)
Introduction: Pancreas-kidney transplant is an effective treatment for patients with insulin-dependent dabetes and chronic renal failure. Reduction in technical failure loss and early acute rejection rates contributed to ...
Clinical Pharmacology and Therapeutic Drug Monitoring of Immunosuppressive Agents
(2013)
Immunosuppressive drugs are used to reduce the immune response in organ transplantation and autoimmune disease. The pharmacokinetics of the immunosuppressive drugs is complex and unpredictable. Therapeutic drug monitoring ...
Current knowledge of immunosuppression as a risk factor for skin cancer development
(2022)
This review outlines our current understanding of the relationship between immunosuppression and skin cancer.
Primary immunodeficiencies increase the incidence of skin cancer, but due to their low frequency, the establishment ...
Immunosuppressive Drugs as a Tool to Explore Immunopathology in Experimental Chagas Disease
(Fundação Oswaldo Cruz. Instituto Oswaldo Cruz, 2020)
Immunosuppressants in Brazil: underlying drivers of spending trends, 2010-2015
(Taylor & Francis, 2019)
Cytotoxic and genotoxic effects of high concentrations of the immunosuppressive drugs cyclosporine and tacrolimus in MRC-5 cells
(Elsevier B.V., 2015-02-01)
Immunosuppressive drugs are used to suppress immune system activity in transplant patients and reduce the risk of organ rejection. The present study evaluated the potential cytotoxic, genotoxic and mutagenic of the ...
Evaluation of a coated blade spray-tandem mass spectrometry assay as a new tool for the determination of immunosuppressive drugs in whole blood
(Springer Heidelberg, 2020-08)
Immunosuppressive drugs (ISDs) are primarily administered following solid organ transplant or for treatment of a variety of autoimmune conditions. Their principal function is to suppress the activity of the immune system; ...
Type B Insulin Resistance in Peru
(Elsevier, 2016)
Type B insulin resistance (IR) is a rare autoimmune disease characterized by the presence of insulin receptor autoantibodies, resulting in a marked IR inducing hyperglycemia. Our first case is a 42-year-old female with a ...