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Immunophenotypic Shifts in Primary Cutaneous gammadelta T-Cell Lymphoma Suggest Antigenic Modulation: A Study of Sequential Biopsy Specimens
(Wolters Kluwer Health, 2017)
Primary cutaneous gammadelta T-cell lymphoma (PCGD TCL), an aggressive type of lymphoma, accounts for approximately 1% of all primary cutaneous lymphomas. We have occasionally observed changes in T-cell antigen expression ...
XBP-1 and the UPRosome: Mastering secretory cell function
(2008)
A unique feature of secretory cells is the proliferation of the endoplasmic reticulum (ER) and Golgi network. The high demand imposed by protein synthesis and folding in secretory cells constitutes an endogenous source of ...
In vitro evaluation of a soluble Leishmania promastigote surface antigen as a potential vaccine candidate against human leishmaniasis
(Public Library of Science, 2014)
PSA (Promastigote Surface Antigen) belongs to a family of membrane-bound and secreted proteins present in several Leishmania (L.) species. PSA is recognized by human Th1 cells and provides a high degree of protection in ...
Anti-Fas2 IgM antibodies in Fasciola hepatica infected patients with positive IgG serology
(Oxford University Press, 2017)
Background: Fascioliasis is an infectious disease caused by parasites Fasciola hepatica and F. gigantica. Humans are infected by the consumption of vegetables and water contaminated with the infective form of the parasite. ...
A validated gene regulatory network and GWAS identifies early regulators of T cell-associated diseases
(American Association for the Advancement of Science, 2015)
Early regulators of disease may increase understanding of disease mechanisms and serve as markers for presymptomatic diagnosis and treatment. However, early regulators are difficult to identify because patients generally ...
B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and FcγRIIb, which are modulated by anti-tumor necrosis factor therapy
(2010)
Introduction: Several molecules help preserve peripheral B cell tolerance, but when altered, they may predispose to autoimmunity. This work studied the expression of the costimulatory molecule CD86 and the inhibitory ...
The innate immunity in alzheimer disease-relevance to pathogenesis and therapy
(Bentham Science Publishers B.V., 2015)
Dissociation between plasma and monocyte‐associated cytokines during sepsis
(1991)
We report our investigations of circulating interleukin (IL) 1β, IL 6 and tumor necrosis factor (TNF)‐α, as well as cell‐associated IL 1α, IL 1β and TNF‐α in plasma and monocytes of 21 patients with sepsis syndrome and 6 ...
Toll-like receptor (TLR) 2 and TLR9 expressed in trigeminal ganglia are critical to viral control during herpes simplex virus 1 infection
(American Society for Investigative Pathology, 2013)