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Regulatory mechanisms of intestinal iron absorption - uncovering of a fast-response mechanism based on DMT1 and ferroportin endocytosis
(Wiley, 2010)
Knowledge on the intestinal iron transport process and the regulation of body iron stores has greatly increased during the last decade. The liver, through the sensing of circulating iron, is now recognized as the central ...
Iron supply determines apical/basolateral membrane distribution of intestinal iron transporters DMT1 and ferroportin 1
(2010)
00168.2009.—Intestinal iron absorption comprises
the coordinated activity of the influx transporter divalent metal
transporter 1 (DMT1) and the efflux transporter ferroportin (FPN). In
this work, we studied the movement ...
Liver iron modulates hepcidin expression during chronically elevated erythropoiesis in mice
(Wiley, 2013)
The liver-derived peptide hepcidin controls the balance between iron demand and iron supply. By inhibiting the iron export activity of ferroportin, hepcidin modulates iron absorption and delivery from the body's stores. ...
The effect of calcium on non-heme iron uptake, efflux, and transport in intestinal-like epithelial cells (Caco-2 cells)
(2012)
It has been suggested that calcium inhibits the absorption of dietary iron by directly affecting enterocytes. However, it is not clear if this effect is due to a decreased uptake of iron or its efflux from enterocytes. We ...
Absorption of Iron from Ferritin Is Independent of Heme Iron and Ferrous Salts in Women and Rat Intestinal Segments
(AMER SOC NUTRITION, 2012-03)
Ferritin iron from food is readily bioavailable to humans and has the potential for treating iron deficiency. Whether ferritin iron absorption is mechanistically different from iron absorption from small iron complexes/salts ...
The cellular mechanisms of body iron homeostasis
(Sociedad de Biología de Chile, 2000)
Regulation of transepithelial transport of iron by hepcidin
(Sociedad de Biología de Chile, 2006)
Role of redox systems on Fe3+ uptake by transformed human intestinal epithelial (Caco-2) cells
(1994)
Caco-2 cells were used as a model of human intestinal epithelium to investigate the role of redox systems in transepithelial transport of 59Fe3+. The cells reduced Fe3+ present in the apical medium; the reduction was 50% ...
DMT1, a physiologically relevant apical Cu1+ transporter of intestinal cells
(2003)
Despite important advances in the under-standing of copper secretion and excretion, the molecular components of intestinal copper absorption remain a mys-tery. DMT1, also known as Nramp2 and DCT1, is the trans-porter ...