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Subcellular localization of an intracellular serine protease of 68 kDa in Leishmania (Leishmania) amazonensis promastigotes
(Fundação Oswaldo Cruz. Instituto Oswaldo Cruz, 2019)
Peptidomic Analysis of HEK293T Cells: Effect of the Proteasome Inhibitor Epoxomicin on Intracellular Peptides
(AMER CHEMICAL SOCWASHINGTON, 2012)
Peptides derived from cytosolic, mitochondrial, and nuclear proteins have been detected in extracts of animal tissues and cell lines. To test whether the proteasome is involved in their formation, HEK293T cells were treated ...
Omp19 enables Brucella abortus to evade the antimicrobial activity from host's proteolytic defense system
(Frontiers Media, 2019-06)
Pathogenic microorganisms confront several proteolytic events in the molecular interplay with their host, highlighting that proteolysis and its regulation play an important role during infection. Microbial inhibitors, along ...
Activated α2-macroglobulin induces Müller glial cell migration by regulating MT1-MMP activity through LRP1
(Federation of American Societies for Experimental Biology, 2013-05)
In retinal proliferative diseases, Müller glial cells (MGCs) acquire migratory abilities. However, the mechanisms that regulate this migration remain poorly understood. In addition, proliferative disorders associated with ...
FRET peptides reveal differential proteolytic activation in intraerythrocytic stages of the malaria parasites Plasmodium berghei and Plasmodium yoelii
(ELSEVIER SCI LTD, 2011)
Malaria is still a major health problem in developing countries. It is caused by the protist parasite Plasmodium, in which proteases are activated during the cell cycle. Ca(2+) is a ubiquitous signalling ion that appears ...
Papel do Receptor Ativado por Protease (PAR)2 no recrutamento de neutrófilos induzido pelo Fator Ativador de Plaquetas (PAF)
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE FARMACOLOGIAPrograma de Pós-Graduação em Ciências Biológicas - Fisiologia e FarmacologiaUFMG, 2021-09-10)
At the lung inflammation microenvironment containing platelet-activating factor (PAF), proteases and protease-activated receptor (PAR)2 are also abundantly present. Despite this evidence, a cooperation between PAF and ...
Avaliação da atividade proteolítica intracelular de cisteíno e serino proteases durante o ciclo intraeritrocítico de Plasmodium falciparum
(Universidade Federal de São Paulo, 2022-02-23)
A malária é uma doença parasitária tropical ocasionada pelo protozoário do gênero Plasmodium. O ciclo de vida do parasito é complexo e envolve um vetor Anopheles responsável pela transmissão da doença para um hospedeiro ...
Inhibition of thimet oligopeptidase by siRNA alters specific intracellular peptides and potentiates isoproterenol signal transduction
(ELSEVIER SCIENCE BVAMSTERDAM, 2012)
Mammalian cells have a large number of intracellular peptides that are generated by extralysosomal proteases. In this study, the enzymatic activity of thimet oligopeptidase (EP24.15) was inhibited in human embryonic kidney ...