Buscar
Mostrando ítems 1-10 de 390
Thy-1-integrin interactions in cis and trans mediate distinctive signaling
(Frontiers Media, 2022)
Thy-1 is a cell surface glycosylphosphatidylinositol (GPI)-anchored glycoprotein that bears a broad mosaic of biological roles across various cell types. Thy-1 displays strong physiological and pathological implications ...
An outside-in switch in integrin signaling caused by chemical and mechanical signals in reactive astrocytes
(Frontiers Media, 2021)
Astrocyte reactivity is associated with poor repair capacity after injury to the brain, where chemical and physical changes occur in the damaged zone. Astrocyte surface proteins, such as integrins, are upregulated, and the ...
Extracellular matrix stiffness and Wnt/β-catenin signaling in physiology and disease
(NLM (Medline), 2020)
Signaling triggered by Thy-1 interaction with β3 integrin on astrocytes is an essential step towards unraveling neuronal Thy-1 function
(2002)
Thy-1 is an abundant neuronal glycoprotein in mammals. Despite such prevalence, Thy-1 function remains largely obscure in the absence of a defined ligand. Recently described evidence that Thy-1 interacts with β3 integrin ...
Substrate engagement of integrins α5 β1 and αv β3 is necessary, but not sufficient, for high directional persistence in migration on fibronectin
(Nature Publishing Group, 2016-03)
The interplay between specific integrin-mediated matrix adhesion and directional persistence in cell migration is not well understood. Here, we characterized fibroblast adhesion and migration on the extracellular matrix ...
Signaling triggered by Thy-1 interaction with ß3 integrin on astrocytes is an essential step towards unraveling neuronal Thy-1 function
(Sociedad de Biología de Chile, 2002)
AhR ligand aminoflavone suppresses α6-integrin–Src–Akt signaling to attenuate tamoxifen resistance in breast cancer cells
(Wiley-liss, Div John Wiley & Sons Inc, 2018-01)
More than 40% of patients with luminal breast cancer treated with endocrine therapy agent tamoxifen demonstrate resistance. Emerging evidence suggests tumor initiating cells (TICs) and aberrant activation of Src and Akt ...
Regulation of Rho Family GTPases by Cell-Cell and Cell-Matrix Adhesion
(Sociedad de Biología de Chile, 2002)
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
(Cell Press, 2009-11)
Tumors are characterized by extracellular matrix (ECM) remodeling and stiffening. The importance of ECM remodeling to cancer is appreciated; the relevance of stiffening is less clear. We found that breast tumorigenesis is ...