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IMT504, the prototype of the immunostimulatory oligonucleotides of the PyNTTTTGT class, increases the number of progenitors of mesenchymal stem cells both in vitro and in vivo: potential use in tissue repair therapy
(Alphamed Press, 2007-04-25)
Bone marrow (BM)-derived adult mesenchymal stem cells (MSCs) have the capacity to differentiate in vitro into different cell lines. This makes them a likely source for application in tissue repair therapies. Here, we report ...
IMT504: A New and Potent Adjuvant for Rabies Vaccines Permitting Significant Dose Sparing
(Scientific Research Publishing Inc, 2012-11)
Background: Rabies virus infection causes encephalitis, which is almost always fatal. Vaccination can be extremely effective at preventing disease but is prohibitively costly. Vaccine formulations allowing dose-sparing and ...
Non-clinical safety studies of IMT504, a unique non-CpG oligonucleotide
(Oxford University Press, 2014-05)
El IMTE 504 es un oligonucleotido de la linea no CgG, el cual estimula diferentes celulas del sistema inmune. El IMT 504 ha sido testeado en diferentes especies animales: raton, conejo, monos y su actividad fue efectiva ...
Oligonucleotide IMT504 reduces neuropathic pain after peripheral nerve injury
(Elsevier Ireland, 2008-10)
We have recently shown that the administration of bone marrow stromal cells (MSCs) prevents the development of mechanical and thermal allodynia in animals subjected to a sciatic nerve injury. Furthermore, exogenously ...
Oligonucleotide IMT504 improves glucose metabolism and controls immune cell mediators in female diabetic NOD mice
(Mary Ann Liebert, 2021-04)
Type 1 diabetes occurs as a consequence of progressive autoimmune destruction of beta cells. A potential treatment for this disease should address the immune attack on beta cells and their preservation/regeneration. The ...
IMT504 Provides Analgesia by Modulating Cell Infiltrate and Inflammatory Milieu in a Chronic Pain Model
(Springer, 2020-11)
IMT504 is a non-CPG, non-coding synthetic oligodeoxinucleotide (ODN) with immunomodulatory properties and a novel inhibitory role in pain transmission, exerting long-lasting analgesic effects upon multiple systemic ...
Proposed mechanisms for oligonucleotide IMT504 induced diabetes reversion in a mouse model of immunodependent diabetes
(American Physiological Society, 2016-07-21)
Type 1 diabetes (T1D) originates from autoimmune β-cell destruction. IMT504 is an immunomodulatory oligonucleotide that increases mesenchymal stem cells cloning capacity and reverts toxic diabetes in rats. Here we evaluated ...
Immunomodulatory oligonucleotide IMT504: effects on mesenchymal stem cells as a first-in-class immunoprotective/immunoregenerative therapy
(Baishideng Publishing Group Inc, 2017-03-26)
The immune responses of humans and animals to insults (i.e., infections, traumas, tumoral transformation and radiation) are based on an intricate network of cells and chemical messengers. Abnormally high inflammation ...
Long-lasting ameliorating effects of the oligodeoxynucleotide IMT504 on mechanical allodynia and hindpaw edema in rats with chronic hindpaw inflammation
(Elsevier Science, 2018-02)
Purpose Previously we showed that systemic administration of IMT504 prevents or ameliorates mechanical and thermal allodynia in rats with sciatic nerve crush. Here we analyzed if IMT504 is also effective in reducing ...