Buscar
Mostrando ítems 1-10 de 58
Role of the Hsp90-immunophilin heterocomplex in cancer disease
(Bentham Science Publishers, 2019)
The identification of new factors that may function as cancer markers and becomeeventual pharmacologic targets is a challenge that may influence the management of tumor developmentand management. Recent discoveries connecting ...
Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus
(American Society for Biochemistry and Molecular Biology, 2004)
The tumor suppressor protein p53 is known to be transported to the nucleus along microtubular tracks by cytoplasmic dynein. However, the connection between p53 and the dynein motor protein complex has not been established. ...
Hsp90-binding immunophilin FKBP51 forms complexes with hTERT enhancing telomerase activity
(Elsevier, 2016-05-17)
FK506-binding proteins are members of the immunophilin family of proteins. Those immunophilins associated to the 90-kDa-heat-shock protein, Hsp90, have been proposed as potential modulators of signalling cascade factors ...
Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51
(Wiley Blackwell Publishing, Inc, 2012-07)
Immunophilin is the collective name given to a family of proteins that bind immunosuppressive drugs: Some immunophilins are Hsp90-binding cochaperones that affect steroid receptor function. Mood and anxiety disorders are ...
Proof that the high molecular weight immunophilin FKBP52 mediates the in vivo neuroregenerative effect of the macrolide FK506
(Pergamon-Elsevier Science Ltd, 2020-12)
The immunosuppressant drug FK506 (or tacrolimus) is a macrolide that binds selectively to immunophilins belonging to the FK506-binding protein (FKBP) subfamily, which are abundantly expressed proteins in neurons of the ...
Neuroregenerative and neuroprotective actions of immunophilin ligands in murine models
(Fundación Revista Medicina, 2017)
Immunophilins (IMMs) are a family of intracellular proteins that bind immunosuppressive drugs. They are referred to as FK506-binding proteins (FKBPs) when they bind FK506, and cyclophilins (CyPs) when they bind cyclosporine ...
Management of cytoskeleton architecture by molecular chaperones and immunophilins
(Elsevier Science Inc, 2011-12)
Cytoskeletal structure is continually remodeled to accommodate normal cell growth and to respond to pathophysiological cues. As a consequence, several cytoskeleton-interacting proteins become involved in a variety of ...
Regulation of NF-kB signalling cascade by immunophilins
(Bentham Science Publishers, 2016-01)
The fine regulation of signalling cascades is a key event required to maintain the appropriate functional properties of a cell when a given stimulus triggers specific biological responses. In this sense, cumulative ...
Peptidyl‐Prolyl Isomerase Activity of Immunophilins Could Be the Mere Consequence of Protein Complex Organization
(John Wiley & Sons Inc, 2020-05)
Immunophilins comprise a family of proteins characterized by the presence of a specific sequence that usually shows peptidyl‐prolyl‐(cis/trans )‐isomerase (PPIase) activity, i.e., the reversible cis/trans interconversion ...
Subcellular rearrangement of Hsp90-binding immunophilins accompanies neuronal differentiation and neurite outgrowth
(Wiley, 2010-11)
FKBP51 and FKBP52 (FK506-binding protein 51 and 52) are tetratricopeptide repeat-domain immunophilins belonging to the tetratricopeptide-protein•hsp90•hsp70•p23 heterocomplex bound to steroid receptors. Immunophilins are ...