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Computational Tools for the Identification and Interpretation of Sequence Motifs in Immunopeptidomes
(Wiley VCH Verlag, 2018-06)
Recent advances in proteomics and mass‐spectrometry have widely expanded the detectable peptide repertoire presented by major histocompatibility complex (MHC) molecules on the cell surface, collectively known as the ...
Immunopeptidomic Data Integration to Artificial Neural Networks Enhances Protein-Drug Immunogenicity Prediction
(Frontiers Media S.A., 2020-06)
Recombinant DNA technology has, in the last decades, contributed to a vast expansion of the use of protein drugs as pharmaceutical agents. However, such biological drugs can lead to the formation of anti-drug antibodies ...
MS-Rescue: A Computational Pipeline to Increase the Quality and Yield of Immunopeptidomics Experiments
(Wiley VCH Verlag, 2019-02)
LC–MS/MS has become the standard platform for the characterization of immunopeptidomes, the collection of peptides naturally presented by major histocompatibility complex molecules to the cell surface. The protocols and ...
Improved Prediction of MHC II Antigen Presentation through Integration and Motif Deconvolution of Mass Spectrometry MHC Eluted Ligand Data
(American Chemical Society, 2020-06)
Major histocompatibility complex II (MHC II) molecules play a vital role in the onset and control of cellular immunity. In a highly selective process, MHC II presents peptides derived from exogenous antigens on the surface ...
Defining the HLA class I-associated viral antigen repertoire from HIV-1-infected human cells
(Wiley VCH Verlag, 2016-01)
Recognition and eradication of infected cells by cytotoxic T lymphocytes is a key defense mechanism against intracellular pathogens. High-throughput definition of HLA class I-associated immunopeptidomes by mass spectrometry ...
Caracterización de la expresión del complejo mayor de histocompatibilidad clase II en monocitos y macrófagos derivados de monocitos bovinos infectados con dos bacterias de relevancia clínica
(Bogotá : Universidad de Ciencias Aplicadas y Ambientales, 2019Facultad de Ciencias AgropecuariasMedicina Veterinaria y Zootecnia, 2019)
The major histocompatibility class II complex (MHC-II) play an important effector role for 7 the adaptive immune response against extracellular pathogens. One of the most popular 8 advances for understanding the antigen ...
NNAlign-MA; MHC peptidome deconvolution for accurate MHC binding motif characterization and improved t-cell epitope predictions
(American Society for Biochemistry and Molecular Biology, 2019-10)
The set of peptides presented on a cell´s surface by MHC molecules is known as the immunopeptidome. Current mass spectrometry technologies allow for identification of large peptidomes, and studies have proven these data ...
Identificación y caracterización de linfocitos T neoantígeno específicos de donantes sanos con fines de inmunoterapia en cáncer
(Universidad Nacional de ColombiaBogotá - Medicina - Maestría en InmunologíaFacultad de MedicinaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá, 2022-11-15)
La inmunoterapia basada en neoantígenos permite estimular el sistema inmune del paciente con cáncer al inducir una respuesta antitumoral dirigida mediada por Linfocitos T (LT). Los neoantígenos son generados por ...