Buscar
Mostrando ítems 1-10 de 211
Pathophysiological mechanisms leading to low platelet count in immune thrombocytopenia
(Journal of Immunological Science, 2020-07-01)
Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by the decrease in peripheral blood platelet count below 100 x 109/L, and an increased bleeding risk when thrombocytopenia drops below 30 x ...
Glycoprotein Ib/IX complex is the target in rifampicin-induced immune thrombocytopenia
(BLACKWELL SCIENCE LTD, 2000)
Thrombocytopenia is a major adverse effect of several drug treatments. Rifampicin has been recognized as a cause of immune thrombocytopenia during intermittent high-dose therapy. We characterized the antibody of a patient ...
Autoantibodies in immune thrombocytopenia affect the physiological interaction between megakaryocytes and bone marrow extracellular matrix proteins
(Wiley Blackwell Publishing, Inc, 2017-10)
Immune thrombocytopenia (ITP) is characterized by itsheterogeneity among patients with regard to both clinicalfeatures and response to treatment. Although there isstill much to investigate, this heterogeneity could be ...
Thrombocytopenia in Dengue: Interrelationship between Virus and the Imbalance between Coagulation and Fibrinolysis and Inflammatory Mediators
(Hindawi Publishing Corporation, 2016)
Oxaliplatin-related thrombocytopenia
(Oxford Univ Press, 2012-08-01)
Oxaliplatin is a third generation platinum compound that inhibits DNA synthesis, mainly through intrastrandal cross-links in DNA. Most of the experience with the clinical use of this drug is derived from colorectal cancer ...
Impaired proplatelet formation in immune thrombocytopenia: a novel mechanism contributing to decreased platelet count
(Wiley, 2014-06)
The pathophysiological mechanisms contributing to the decreased platelet count in immune thrombocytopenia (ITP) are not entirely understood. Here, we investigated the key step of proplatelet formation (PPF) by studying the ...
Treatment of heparin-induced thrombocytopenia with rivaroxaban. Case report
(SOC MEDICA SANTIAGO, 2017)
Heparin-induced thrombocytopenia (HIT) is immune-mediated. It occurs more frequently with unfractionated heparin (UFH) than with low molecular weight heparins (LMWH). It is associated with thromboembolic rather than ...