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Rethinking interleukin-6 blockade for treatment of COVID-19
Interleukin-6 (IL-6) is a pleiotropic cytokine with effects in immune regulation, inflammation, and infection. The
use of drugs that inhibit IL-6 biological activity has been proposed as a treatment for patients with ...
Electrical stimulation induces IL-6 in skeletal muscle through extracellular ATP by activating Ca2 signals and an IL-6 autocrine loop
(American Physiological Society, 2014)
S. Electrical stimulation induces IL-6 in skeletal muscle through
extracellular ATP by activating Ca2 signals and an IL-6 autocrine
loop. Am J Physiol Endocrinol Metab 306: E869 –E882, 2014. First
published February ...
Selective blockade of lymphopoiesis induced by kalanchosine dimalate: inhibition of IL-7-dependent proliferation
(Society for Leukocyte Biology, 2019)
The influence of adrenergic blockade in rats with apical periodontitis under chronic stress conditions
(2020-02-01)
Objective: To investigate the influence of chronic stress and adrenergic blockade in a rat model of apical periodontitis. Methods: Thirty-two Wistar rats were submitted to an animal model of periapical lesion and randomly ...
Blockade of central kappa-opioid receptors inhibits the antidipsogenic effect of interleukin-1β
(Brasil, 2009)
The objective of the present study was to investigate the role of brain kappa-opioid receptors (KOR) in the antidipsogenic effect promoted by third ventricle injections of interleukin-1β (IL-1β). Wistar male rats were ...
Electrical stimulation induces IL-6 in skeletal muscle through extracellular ATP by activating Ca2+ signals and an IL-6 autocrine loop
(American Physiological Society, 2014)
Interleukin-6 (IL-6) is an important myokine that is highly expressed in skeletal muscle cells upon exercise. We assessed IL-6 expression in response to electrical stimulation (ES) or extracellular ATP as a known mediator ...
The chronic blockade of angiotensin I-converting enzyme eliminates the sex differences of serum cytokine levels of spontaneously hypertensive rats
(Assoc Bras Divulg Cientifica, 2013-02-01)
Sex hormones modulate the action of both cytokines and the renin-angiotensin system. However, the effects of angiotensin I-converting enzyme (ACE) on the proinflammatory and anti-inflammatory cytokine levels in male and ...
Chronic blockade of the AT2 receptor with PD123319 impairs insulin signaling in C57BL/6 mice
(Elsevier Science Inc, 2017-02)
The renin-angiotensin system modulates insulin action. Angiotensin type 1 receptor exerts a deleterious effects while the angiotensin type 2 receptor (AT2R) appears to have beneficial effects providing protection against ...