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Optimal clearance of Sporothrix schenckii requires an intact Th17 response in a mouse model of systemic infection
(Elsevier B.V., 2015-08-01)
The discovery of Th17 cells, along with many other Th cell subsets in the recent years, has expanded the Th1/Th2 paradigm that had persisted since its proposition by Mosmann in 1986. Defined by the characteristic expression ...
Dual role of interleukin-4 (IL-4) in pulmonary paracoccidioidomycosis: Endogenous IL-4 can induce protection or exacerbation of disease depending on the host genetic pattern
(Amer Soc Microbiology, 2004-07-01)
Resistance to paracoccidioidomycosis, the most important endemic mycosis in Latin America, is thought to be primarily mediated by cellular immunity and the production of gamma interferon. To assess the role of interleukin-4 ...
Neutrófilos têm um papel protetor durante os estágios iniciais da infecção por Leishmania amazonensis em camundongos BALB/c
(Universidade Federal de Minas GeraisUFMG, 2013-10-24)
Neutrophils are involved in early stages of immune response to pathogens. In the present work, we investigated the role of neutrophils during the establishment of Leishmania amazonensis infection in BALB/c and C57BL/6 mice. ...
Long-term testosterone depletion attenuates inflammatory bone resorption in the ligature-induced periodontal disease model
(Amer Acad Periodontology, 2018-04-01)
Background: Testosterone is known to affect bone in physiological and pathological conditions. The purpose of this study is to evaluate the role of testosterone in experimental periodontal disease in rats. Methods: In this ...
Depletion of dendritic cells enhances innate anti-bacterial host defense through modulation of phagocyte homeostasis
(Public Library of Science, 2012-02)
Dendritic cells (DCs) as professional antigen-presenting cells play an important role in the initiation and modulation of the adaptive immune response. However, their role in the innate immune response against bacterial ...
CD25(+) T cell depletion impairs murine squamous cell carcinoma development via modulation of antitumor immune responses
(OXFORD UNIV PRESSOXFORD, 2012)
Squamous cell carcinoma (SCC) constitutes a microenvironment that could modulate the antitumor immune response. Also, tumor-infiltrating lymphocytes are believed to play complex regulatory roles in antitumor immunity against ...