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Fisiologia do eixo GH-sistema IGF
(Sociedade Brasileira de Endocrinologia e Metabologia, 2008)
O crescimento, principal característica da infância e da adolescência, apresenta padrão semelhante na maioria dos indivíduos. A herança genética e os componentes do eixo GH-IGF são os fatores que diretamente influenciam ...
Immunolocalization of the insulin like growth factor-1 (IGF-1) and IGF-1 receptor (IGF-1R) in the ovary of the bitch
(Wiley-Blackwell, 2012-06-01)
IGF-I regulates pheochromocytoma cell proliferation and survival in vitro and in vivo
(Endocrine Society, 2012-08)
IGFs are involved in malignant transformation and growth of several tissues, including the adrenal medulla. The present study was designed to evaluate the impact of IGF-I on pheochromocytoma development. We used a murine ...
Type 1 IGF Receptor Localization in Paediatric Gliomas: Significant Association with WHO Grading and Clinical Outcome
(Springer, 2018-06)
Nuclear localization of insulin-like growth factor receptor type 1 (IGF-1R) has been described as adverse prognostic factor in some cancers. We studied the expression and localization of IGF-1R in paediatric patients with ...
Expression and protein content of IGF-I and IGF-I receptor in placentas from small, adequate and large for gestational age newborns
(2010)
In humans, a direct relationship between IGF-I cord blood levels and birth weight has been demonstrated. To determine the placental IGF-I, IGF-II and IGF-IR mRNA and protein contents in full-term pregnancies from appropriate ...
Impact of hypoxia on IGF-I, IGF-II, IGFBP-3, ALS and IGFBP-1 regulation and on IGF1R gene expression in children
(CHURCHILL LIVINGSTONEEDINBURGH, 2012)
Hypoxia is one of many factors involved in the regulation of the IGF system. However, no information is available regarding the regulation of the IGF system by acute hypoxia in humans. Objective: The aim of this study was ...
Igf2 And Igf1r In Pediatric Adrenocortical Tumors: Roles In Metastasis And Steroidogenesis
(BIOSCIENTIFICA LTDBRISTOL, 2016)
Expanding Genetic and Functional Diagnoses of IGF1R Haploinsufficiencies
(Karger, 2017)
Background: The growth-promoting effects of IGF-I is mediated through the IGF-I receptor (IGF1R), a widely expressed cell-surface tyrosine kinase receptor. IGF1R copy number variants (CNV) can cause pre- and postnatal ...