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Endogenous accumulation of IFN-gamma in IFN-gamma-R-/- mice increases resistance to B16F10-Nex2 murine melanoma: a model for direct IFN-gamma anti-tumor cytotoxicity in vitro and in vivo
(Taylor & Francis As, 2002-06-01)
Syngeneic IFN-gamma - / - and IRF-1 - / - mice are very sensitive to B16F10-Nex2 murine melanoma cells implanted subcutaneously. in contrast, IFN-gamma-R - / - (GRKO) mice are remarkably resistant to tumor development. ...
Normal expression of IFN-gR in four patients with uncommon mycobacterial infection phenotypes
(2004)
Several primary immunodeficiency diseases affecting the interleukin 12/interferon gamma (IFN-g) pathway have been identified, most of them characterized by recurrent and protracted infections produced by intracellular ...
IFN-gamma production by CD8+ T cells depends on NFAT1 transcription factor and regulates Th differentiation
(American Association of Immunologists, 2020)
Boosting the suppressive effects of Ascaris suum components in IFN-γ-deficient mice
(Sociedade Brasileira de Medicina Tropical - SBMT, 2009)
High molecular weight components from Ascaris suum extract suppress ovalbumin-specific immunity in mice. In IFN-γ-deficient mice, ovalbumin-specific delayed-type hypersensitivity reactions are more strongly downregulated ...
Propolis: lymphocyte proliferation and IFN-gamma production
(Elsevier B.V., 2003-07-01)
We evaluated propolis influence on polyclonal activation of lymphocytes by concanavalin A (Con A). The in vitro experiments showed that propolis decreases splenocyte proliferation both in the absence or presence of Con A. ...
Propolis: lymphocyte proliferation and IFN-gamma production
(Elsevier B.V., 2003-07-01)
We evaluated propolis influence on polyclonal activation of lymphocytes by concanavalin A (Con A). The in vitro experiments showed that propolis decreases splenocyte proliferation both in the absence or presence of Con A. ...
Type I IFN deficiency: an immunological characteristic of severe COVID-19 patients
Recently, a paper published in Science by Hadjadj et al. reported
that type I interferon (IFN) deficiency, could be a hallmark of
severe coronavirus disease 2019 (COVID-19) caused by severe
acute respiratory syndrome ...