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White adipose tissue IFN-γ expression and signalling along the progression of rodent cancer cachexia
(2017-01-01)
Cachexia is associated with increased morbidity and mortality in cancer. The White adipose tissue (WAT) synthesizes and releases several pro-inflammatory cytokines that play a role in cancer cachexia-related systemic ...
Foot-and-mouth disease vaccination induces cross-reactive IFN-γ responses in cattle that are dependent on the integrity of the140S particles
(Academic Press Inc Elsevier Science, 2014-12)
Interferon-γ (IFN-γ) recall responses against foot-and-mouth disease virus (FMDV) in FMD vaccinated cattle are utilized to study T-lymphocyte immunity against this virus. Here, a recall IFN-γ assay based on a commercial ...
IFN-γ production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB
(University of Chicago Press, 2009-03)
Interferon-γ (IFN-γ) is crucial for protection against Mycobacterium tuberculosis, and the transcription factor cAMP response element binding protein (CREB) increases IFN-γ transcription. We determined whether the transmembrane ...
Spontaneous Neutrophil Activation in HTLV-1 Infected Patients
(The Brazilian Journal of Infectious Diseases, 2005)
Human T cell lymphotropic Virus type-1 (HTLV-1) induces lymphocyte activation and
proliferation, but little is known about the innate immune response due to HTLV-1 infection. We
evaluated the percentage of neutrophils that ...
IL-17 and IFN-γ expression in lymphocytes from patients with active tuberculosis correlates with the severity of the disease
(Society for Leukocyte Biology, 2012)
Abstract: Th1 lymphocytes are crucial in the immune response against Mycobacterium tuberculosis. Nevertheless, IFN-γ alone is not sufficient in the complete eradication of the bacteria, suggesting that other cytokines might ...
CCR6 and NK1.1 distinguish between IL-17A and IFN-γ-producing γδ effector T cells
(2009)
γδ T cells are a potent source of innate IL-17A and IFN-γ, and they acquire the capacity to produce these cytokines within the thymus. However, the precise stages and required signals that guide this differentiation are ...
IL-12 and IFN-γ production, and NK cell activity, in acute and chronic experimental Trypanosoma cruzi infections
(Elsevier Science, 2000-02)
Resistance to acute Trypanosoma cruzi infection is mainly associated with a Th1 immune response, characterized by gamma-interferon (IFN-γ) production and activation of macrophages. The outcome of the Th1 response in the ...
Phosphorylation of Mitogen-Activated Protein Kinases Contributes to Interferon γ Production in Response to Mycobacterium tuberculosis
(Oxford University Press, 2012-12)
Immune control of Mycobacterium tuberculosis depends on interferon γ (IFN-γ)–producing CD4+ lymphocytes. Previous studies have shown that T cells from patients with tuberculosis produce less IFN-γ, compared with healthy ...