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Endogenous accumulation of IFN-gamma in IFN-gamma-R-/- mice increases resistance to B16F10-Nex2 murine melanoma: a model for direct IFN-gamma anti-tumor cytotoxicity in vitro and in vivo
(Taylor & Francis As, 2002-06-01)
Syngeneic IFN-gamma - / - and IRF-1 - / - mice are very sensitive to B16F10-Nex2 murine melanoma cells implanted subcutaneously. in contrast, IFN-gamma-R - / - (GRKO) mice are remarkably resistant to tumor development. ...
Propolis: lymphocyte proliferation and IFN-gamma production
(Elsevier B.V., 2003-07-01)
We evaluated propolis influence on polyclonal activation of lymphocytes by concanavalin A (Con A). The in vitro experiments showed that propolis decreases splenocyte proliferation both in the absence or presence of Con A. ...
Propolis: lymphocyte proliferation and IFN-gamma production
(Elsevier B.V., 2003-07-01)
We evaluated propolis influence on polyclonal activation of lymphocytes by concanavalin A (Con A). The in vitro experiments showed that propolis decreases splenocyte proliferation both in the absence or presence of Con A. ...
Imbalance of IL-2, IFN-gamma and IL-10 secretion in the immunosuppression associated with human paracoccidioidomycosis
(W B Saunders Co, 2001-02-21)
Patients with paracoccidioidomycosis (PCM) display a certain degree of immunecompromise characterized by lymphocyte hyporesponsiveness to the main Paracoccidioides brasiliensis antigen (gp43). To determine whether cytokines ...
IFN-gamma production by CD8+ T cells depends on NFAT1 transcription factor and regulates Th differentiation
(American Association of Immunologists, 2020)
Stage-specific role of interferon-gamma in experimental autoimmune encephalomyelitis and multiple sclerosis
(Frontiers Media, 2015)
The role of interferon (IFN)-gamma in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), has remained as an enigmatic paradox for more than 30 years. Several studies attribute ...
Stage-specific role of interferon-gamma in experimental autoimmune encephalomyelitis and multiple sclerosis
(2015)
The role of interferon (IFN)-gamma in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), has remained as an enigmatic paradox for more than 30 years. Several studies attribute ...
The effect of propolis on CCL5 and IFN-gamma expression by peripheral blood mononuclear cells from leishmaniasis patients
(Wiley-Blackwell, 2012-01-01)
Objectives Mucocutaneous leishmaniasis is associated with a strong Th1 immune response to Leishmania, which modulates chemokines and their receptors expression, affecting their migratory capacity. There are no antileishmanial ...
The effect of propolis on CCL5 and IFN-gamma expression by peripheral blood mononuclear cells from leishmaniasis patients
(Wiley-Blackwell, 2012-01-01)
Objectives Mucocutaneous leishmaniasis is associated with a strong Th1 immune response to Leishmania, which modulates chemokines and their receptors expression, affecting their migratory capacity. There are no antileishmanial ...
Paracoccidioidomycosis Associated With a Heterozygous STAT4 Mutation and Impaired IFN-gamma Immunity
(Oxford Univ Press Inc, 2017-12-15)
Background. Mutations in genes affecting interferon-gamma (IFN-gamma) immunity have contributed to understand the role of IFN-gamma in protection against intracellular pathogens. However, inborn errors in STAT4, which ...