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Comparison of the pharmacological activity of idarubicin and doxorubicin for retinoblastoma
(Veterinary and Human Toxicology, 2019-01)
Differential antigenotoxic and cytoprotective effect of amifostine in idarubicin-treated mice
(Wiley-liss, Inc, 2002-12)
In this study we evaluated the antigenotoxic and cytoprotective capabilities of WR-2721 [S-2-(3aminopropylamino)-ethylphosphorothioic acid (amifostine)] in different normal tissues of BALB/c mice treated with idarubicin ...
Correlation between chromosome damage and apoptosis induced by fludarabine and idarubicin in normal human lymphocytes
(Elsevier Ireland, 2002-02)
Fludarabine (FLU, a fluorinated purine analog) and idarubicin (IDA, a DNA-topoisomerase II poison) are frequently used in cancer chemotherapy. The effects of these drugs on cultured normal human lymphocytes were studied ...
Daño genético persistente inducido por venenos de topoisomerasa II en fibroblastos humanos normales: generación de inestabilidad cromosómicaPersistent genetic damage induced by topoisomerase II poisons in normal human fibroblasts: generation of chromoso me instability
(Sociedad Argentina de Genética, 2016-12)
Topoisomerase II (Top2) poisons idarubicin (IDA) and etoposide (ETO) are anticancer drugs that target Top2 stabilizing DNA-enzymecomplexes and generating double-strand breaks (DSB). These DNA lesions are dangerous because ...
All-trans retinoic acid with daunorubicin or idarubicin for risk-adapted treatment of acute promyelocytic leukaemia: a matched-pair analysis of the PETHEMA LPA-2005 and IC-APL studies
(Springer, 2015)
Front-line treatment of acute promyelocytic leukaemia (APL) consists of all-trans retinoic acid (ATRA) and anthracycline-based chemotherapy. In this setting, a comparison of idarubicin and daunorubicin has never been carried ...
DNA-PKcs-dependent NHEJ pathway supports the progression of topoisomerase II poison-induced chromosome aberrant cells
(Wiley-liss, Div John Wiley & Sons Inc, 2012-10)
The role of DNA double strand break (DSB) repair pathways, non-homologous end joining (NHEJ), and homologous recombination (HR) was evaluated to prevent the chromosome instability induced by the topoisomerase II (Top2) ...
Manual farmacoterapêutico das antraciclinas com ênfase na cardiotoxicidadeAnthracycline pharmacotherapeutic manual with emphasis on cardiotoxicity
(Universidade Federal do Rio Grande do NorteBrasilUFRNHospital Universitário Onofre Lopes, 2023)