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Computational and experimental approaches for chitosan-based nano PECs design: Insights on a deeper comprehension of nanostructure formation
(2021-02-15)
Nanostructured polyelectrolyte complexes (nano PECs) based on biopolymers are an important technological strategy to target drugs to the action and/or absorption site in a more effective way. In this work, computational ...
Preclinical evaluation of methotrexate-loaded polyelectrolyte complexes and thermosensitive hydrogels as treatment for rheumatoid arthritis
(2021-08-01)
This work proposes new methotrexate (MTX) loaded drug delivery systems (DDS) to treat rheumatoid arthritis via the intra-articular route: a poloxamer based thermosensitive hydrogel (MTX-HG), oligochitosan and hypromellose ...
Design of mucoadhesive nanostructured polyelectrolyte complexes based on chitosan and hypromellose phthalate for metronidazole delivery intended to the treatment of helicobacter pylori infections
(2020-12-01)
Metronidazole (MT) is an important drug available for Helicobacter pylori infection treatment. However, in the past few years, this drug has presented effective reduction for infection control, one of the most important ...
Mucoadhesive Nanostructured polyelectrolyte complexes as potential carrier to improve zidovudine permeability
(2016-02-01)
Mucoadhesive drug delivery systems have been widely investigated as a strategic to allow the raising of intestinal residence time of drugs and the intimate contact with the intestinal mucosa, both factors that increase the ...
A novel approach in mucoadhesive drug delivery system to improve zidovudine intestinal permeability
(2016-10-01)
Zidovudine (AZT) mucoadhesive solid dispersions (SD) were prepared using a sodium starch glycolate (SSG) and hypromellose phthalate (HPMCP) mixtures as carrier to enhance the intestinal permeability and bioavailability of ...
Hpmcp-coated microcapsules containing the ctx(Ile21)-ha antimicrobial peptide reduce the mortality rate caused by resistant salmonella enteritidis in laying hens
(2021-06-01)
The constant use of synthetic antibiotics as growth promoters can cause bacterial resistance in chicks. Consequently, the use of these drugs has been restricted in different countries. In recent years, antimicrobial peptides ...
Mucoadhesive nanostructured polyelectrolytes complexes modulate the intestinal permeability of methotrexate
(2018-01-01)
Nanostructured polyelectrolytes complexes (nano PECs) loaded with methotrexate (MTX) were obtained by the polyelectrolyte complexation of chitosan (CS) and hyaluronic acid (HA), further incorporating hypromellose phthalate ...