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Mechanisms of cardiovascular protection associated with intermittent hypobaric hypoxia exposure in a rat model: role of oxidative stress
(MDPI, 2018)
More than 140 million people live and works (in a chronic or intermittent form) above 2500 m worldwide and 35 million live in the Andean Mountains. Furthermore, in Chile, it is estimated that 55,000 persons work in high ...
Biomechanical and structural responses of the aorta to intermittent hypobaric hypoxia in a rat model
(Nature, 2022)
High altitude hypoxia is a condition experienced by diverse populations worldwide. In addition,
several jobs require working shifts where workers are exposed to repetitive cycles of hypobaric
hypoxia and normobaric ...
Long-Term Chronic Intermittent Hypobaric Hypoxia in Rats Causes an Imbalance in the Asymmetric Dimethylarginine/Nitric Oxide Pathway and ROS Activity: A Possible Synergistic Mechanism for Altitude Pulmonary Hypertension?
(Hindawi, 2016)
Chronic intermittent hypoxia (CIH) and chronic hypoxia (CH) are associated with high-altitude pulmonary hypertension (HAPH). Asymmetric dimethylarginine (ADMA), a NO synthase (NOS) inhibitor, may contribute to HAPH. This ...
Cardioprotective antioxidant and anti-inflammatory mechanisms induced by intermittent hypobaric hypoxia
(MDPI, 2022)
More than 80 million people live and work (in a chronic or intermittent form) above 2500 masl, and 35 million live in the Andean Mountains. Furthermore, in Chile, it is estimated that 100,000 people work in high-altitude ...
Protective effects of polyunsatutared fatty acids supplementation against testicular damage induced by intermittent hypobaric hypoxia in rats
(BioMed Central, 2015)
Background: Intermittent hypobaric hypoxia (IHH) induces changes in the redox status and structure in rat testis.
These effects may be present in people at high altitudes, such as athletes and miners. Polyunsaturated fatty ...
Pharmacological models and approaches for pathophysiological conditions associated with hypoxia and oxidative stress
(Pergamon-Elsevier, 2016)
Hypoxia is the failure of oxygenation at the tissue level,where the reduced oxygen delivered is not enough to satisfy
tissue demands. Metabolic depression is the physiological adaptation associated with reduced oxygen ...
Pharmacological approaches in either intermittent or permanent hypoxia: A tale of two exposures
(Elsevier, 2015)
Hypoxia induces several responses at cardiovascular, pulmonary and reproductive levels, which may lead to chronic diseases. This is relevant in human populations exposed to high altitude (HA), in either chronic continuous ...