The main objective of the present study was to find suitable DNA-targeting sequences (DTS) for the construction of plasmid vectors to be used to treat ischemic diseases. The well-known Simian virus 40 nuclear DTS (SV40-DTS) ...

Hypoxia, a common condition of the tumor microenvironment, induces changes in the proteome of cancer cells, mainly via HIF-1, a transcription factor conformed by a constitutively expressed β-subunit and an oxygen-regulated ...

Aquaporins (AQPs) constitute a family of small transmembrane proteins that facilitate osmotically-driven water transport, and in some cases that of small solutes. Several roles for AQPs have been identified, such as the ...

Adaptation to hypoxia depends on a conserved α/β heterodimeric transcription factor called Hypoxia Inducible Factor (HIF), whose α-subunit is regulated by oxygen through different concurrent mechanisms. In this study, we ...

Hypoxia-inducible factors (HIFs) are a family of evolutionary conserved alpha-beta heterodimeric transcription factors that induce a wide range of genes in response to low oxygen tension. Molecular mechanisms that mediate ...

Aquaporins (AQPs) constitute a familyof small transmembrane proteins that facilitate osmotically-driven watertransport, and in some cases that of small solutes. Several roles for AQPs havebeen identified, such as the ...

Research question: We recently reported that blocking of placental aquaporins (AQP) abrogates the apoptotic response of the trophoblast. As trophoblast apoptosis is exacerbated in pre-eclampsia, we hypothesized that changes ...

INTRODUCCIÓN: Estudios previos de nuestro laboratorio evidenciaron que la GTPasa pequeña Rab5 promueve la adquisición y mantención de características de malignidad tumoral en condiciones de hipoxia, lo cual pareciera ser ...