Buscar
Mostrando ítems 1-10 de 12
Hydroxyestradiols and methoxyestradiols as endogenous factors associated to physiological and physiopathological conditions
(Nova Science Publishers, 2013)
Estradiol (E2) is a steroidal hormone generated by the conversion of testosterone via
the p450 aromatase enzymatic complex. The E2 physiological actions are mainly
mediated by its interaction with intracellular receptors ...
In Vitro maturation of fully grown mouse antral follicles in the presence of 1 nM 2-Hydroxyestradiol improves Oocytes’ developmental competence
(Springer, 2020)
Cathecolestrogens are estradiol metabolites produced during folliculogenesis in the mammalian ovary. 2-Hydroxyestradiol (2-OHE2) is one of the most abundant although its role remains unknown. The aim of this study is to ...
Significance of pro-angiogenic estrogen metabolites in normal follicular development and follicular growth arrest in polycystic ovary syndrome
(Oxford, 2020)
STUDY QUESTION: Do alterations in pro- and anti-angiogenic estrogen metabolites in follicular fluid (FF) contribute to the follicular growth arrest and anovulation associated with polycystic ovary syndrome (PCOS)?
SUMMARY ...
Contribution of alpha(2)-adrenoceptors to the mitogenic effect of catecholestrogen in human breast cancer MCF-7 cells
(Elsevier, 2008)
Catecholestrogens are estrogen metabolites formed by hydroxylation of 17beta-estradiol and estrone at either the C-2 or C-4 position, rivaling the parent estrogens in concentration. The objective of the present work was ...
Disturbed testicular expression of the estrogen-metabolizing enzymes CYP1A1 and COMT in infertile men with primary spermatogenic failure: possible negative implications on Sertoli cells
(Blackwell Publishing Ltd, 2017)
© 2017 American Society of Andrology and European Academy of Andrology Estradiol (E2) is normally metabolized to hydroxyestradiols and methoxyestradiols by CYP1A1, CYP1B1 and COMT. However, an altered production of these ...
Liquid chromatography–time-of-flight high-resolution mass spectrometry study and determination of the dansylated products of estrogens and their hydroxylated metabolites in water and wastewater
(Springer Verlag, 2018)
© 2018, Springer-Verlag GmbH Germany, part of Springer Nature. A method combining liquid chromatography with a dual-probe ultraspray electrospray ionization (ESI) source and time-of-flight high-resolution mass spectrometry ...
Role of 2-methoxyestradiol, an Endogenous Estrogen Metabolite, in Health and Disease
(Bentham Science, 2015)
Estradiol (E-2) is a steroid hormone whose physiological actions are mainly mediated by its interaction with intracellular estrogen receptors (ER) leading to modification on the mRNA and protein synthesis in its target ...