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Effects of Escherichia Coli subtilase cytotoxin and shiga toxin 2 on primary cultures of human renal tubular epithelial cells
(Public Library of Science, 2014-01)
Shiga toxin (Stx)-producing Escherichia coli (STEC) cause post-diarrhea Hemolytic Uremic Syndrome (HUS), which is the most common cause of acute renal failure in children in many parts of the world. Several non-O157 STEC ...
A glucosylceramide synthase inhibitor prevents the cytotoxic effects of Shiga toxin-2 on human renal tubular epithelial cells
(Bentham Science Publishers, 2008-12)
Shiga toxin-2 binds to the globotriaosyl-ceramide receptor on the plasma membrane of target cells. The highlevel expression of this receptor in renal epithelial cells may account, at least in part, for acute renal failure ...
Estradiol stimulates cell proliferation via classic estrogen receptor-alpha and G protein-coupled estrogen receptor-1 in human renal tubular epithelial cell primary cultures
(Academic Press Inc Elsevier Science, 2019-04)
This work was aimed to determine the effect of 17β-estradiol (17βE) on cell proliferation in human renal tubular epithelial cells (HRTEC) isolated from kidneys from pediatric subjects, as well as the role of estrogen ...
Cytotoxic effect of Shiga toxin-2 holotoxin and its B subunit on human renal tubular epithelial cells
(Elsevier Science, 2006-02)
Shiga toxin-producing Escherichia coli produces watery diarrhea, hemorrhagic colitis and hemolytic-uremic syndrome (HUS). In Argentina, HUS is the most common cause of acute renal failure in children. The purpose of the ...
Carvedilol protects against apoptotic cell death induced by cisplatin in renal tubular epithelial cells
(TAYLOR & FRANCIS INCPHILADELPHIA, 2012)
Cisplatin is a highly effective chemotherapeutic drug; however, its use is limited by nephrotoxicity. Studies showed that the renal injury produced by cisplatin involves oxidative stress and cell death mediated by apoptosis ...
Inhibition of water absorption in human proximal tubular epithelial cells in response to Shiga toxin-2
(Springer, 2008)
Postdiarrhea hemolytic uremic syndrome (HUS) is the most common cause of acute renal failure in children in Argentina. It is well established that Shiga toxin type 2 (Stx2) causes direct damage to glomerular endothelial ...
Comparative Characterization of Shiga Toxin Type 2 and Subtilase Cytotoxin Effects on Human Renal Epithelial and Endothelial Cells Grown in Monolayer and Bilayer Conditions
(Public Library of Science, 2016-06-23)
Postdiarrheal hemolytic uremic syndrome (HUS) affects children under 5 years old and is responsible for the development of acute and chronic renal failure, particularly in Argentina. This pathology is a complication of ...
Crosstalk between human microvascular endothelial cells and tubular epithelial cells modulates pro-inflammatory responses induced by Shiga toxin type 2 and subtilase cytotoxin
(MDPI AG, 2019-11)
Hemolytic uremic syndrome (HUS) is a consequence of Shiga toxin (Stx)-producingEscherichia coli (STEC) infection and is the most frequent cause of acute renal failure (ARF) in children. Subtilase cytotoxin (SubAB) has also ...
Human Cytomegalovirus Inhibits Autophagy of Renal Tubular Epithelial Cells and Promotes Cellular Enlargement
(Frontiers Media, 2020-09)
Human Cytomegalovirus (HCMV) is a frequent opportunistic pathogen in immunosuppressed patients, which can be involved in kidney allograft dysfunction and rejection. In order to study the pathophysiology of HCMV renal ...
Efecto citotóxico de la toxina Shiga tipo 2 y su subunidad B en células epiteliales tubulares renales humanas en cultivoCytotoxic effect of Shiga toxin type 2 and its B subunit on human renal tubular epithelial cell cultures
(Medicina (Buenos Aires), 2005-12)
Escherichia coli enterohemorrágica productora de toxina Shiga (Stx) causa diarrea acuosa, colitis hemorrágica y síndrome urémico hemolítico (SUH). En Argentina, el SUH es la principal causa de insuficiencia renal en niños. ...