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Structure- and Ligand-Based Structure-Activity Relationships for a Series of Inhibitors of Aldolase
(BENTHAM SCIENCE PUBL LTDSHARJAH, 2012)
Aldolase has emerged as a promising molecular target for the treatment of human African trypanosomiasis. Over the last years, due to the increasing number of patients infected with Trypanosoma brucei, there is an urgent ...
The use of sulfonamide derivatives in the treatment of trypanosomatid parasites including trypanosoma cruzi, trypanosoma brucei, and leishmania ssp
(2020-01-01)
More than 10 million people around the world are afflicted by Neglected Tropical Diseases, such as Chagas Disease, Human African Trypanosomiasis, and Leishmania. These diseases mostly occur in undeveloped countries that ...
Human african trypanosomiasis: current standing and challenges
(Universidade Federal de Goiás, 2020)
Thiazole, thio and semicarbazone derivatives against tropical infective diseases: Chagas disease, human African trypanosomiasis (HAT), leishmaniasis, and malaria
(2019-01-15)
Thiazole, thiosemicarbazone and semicarbazone moieties are privileged scaffolds (acting as primary pharmacophores) in many compounds that are useful to treat several diseases, mainly tropical infectious diseases. In this ...
Structure-based drug design studies on a series of aldolase inhibitors
(Sociedade Brasileira de Química - SBQSão Paulo, 2013)
Human African trypanosomiasis, also known as sleeping sickness, is a major cause of death in Africa, and for which there are no safe and effective treatments available. The enzyme aldolase from Trypanosoma brucei is an ...