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HPA-1a/1b could be considered a molecular predictor of poor prognosis in chronic hepatitis C
(2019-01-01)
Introduction: HPA polymorphism has been associated with HCV presence and fibrosis progression in chronic hepatitis C. However, it is unknown if there is an association between HPA-1 polymorphism and hepatocellular carcinoma ...
An Atypical Age-Specific Pattern of Hepatocellular Carcinoma in Peru: A Threat for Andean Populations
(Public Library of Science, 2013)
In South America, the highest incidence of primary liver cancer is observed in Peru. However, national estimations on hepatocellular carcinoma incidence and mortality are approximated using aggregated data from surrounding ...
National trends of hepatocellular carcinoma mortality registered by the ministry of health in Peru, from 2005 to 2016
(Sociedad Argentina de Gastroenterologia, 2020-12-01)
Background. Hepatocellular carcinoma results in most cases from underlying chronic liver disease. The most common causes are the Hepatitis B virus and the Hepatitis C virus in-fections, the alcoholism and the aflatoxin. ...
Identification of hepatic stem/progenitor cells in canine hepatocellular and cholangiocellular carcinoma
(WILEY-BLACKWELL, 2010)
Hepatic progenitor cells (HPCs) are bipotential stem cells residing in human and animal livers that are able to differentiate towards the hepatocytic or cholangiocytic lineages. HPCs are present in both hepatocellular (HCC) ...
Dual RNA-seq identifies human mucosal immunity protein Mucin-13 as a hallmark of Plasmodium exoerythrocytic infection
(Springer Nature, 2019)
The exoerythrocytic stage of Plasmodium infection is a critical window for prophylactic intervention. Using genome-wide dual RNA sequencing of flow-sorted infected and uninfected hepatoma cells we show that the human mucosal ...
Negative serology of Fasciola hepatica infection in patients with liver cancer in Peru: a preliminary report
(Sociedade Brasileira de Medicina Tropical, 2018)
INTRODUCTION: The etiology of several hepatocellular carcinoma (HCC) cases remains largely unknown. Although Fasciola hepatica has been associated with liver fibrosis in Latin America, it has not yet been associated with ...
IL-8, GRO and MCP-1 produced by hepatocellular carcinoma microenvironment determine the migratory capacity of human bone marrow-derived mesenchymal stromal cells without affecting tumor aggressiveness
(Impact Journals, 2016-06)
New therapies are needed for advanced hepatocellular carcinoma (HCC) and the use of mesenchymal stromal cells (MSCs) carrying therapeutic genes is a promising strategy. HCC produce cytokines recruiting MSCs to the tumor ...
A comprehensive study of epigenetic alterations in hepatocellular carcinoma identifies potential therapeutic targets
(Elsevier Science, 2019-03)
Background & Aims: A causal link has recently been established between epigenetic alterations and hepatocarcinogenesis, indicating that epigenetic inhibition may have therapeutic potential. We aimed to identify and target ...