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Elevated carbon dioxide upregulates NBCn1 Na+/HCO3− cotransporter in human embryonic kidney cells
(American Physiological Society, 2013-12)
The NBCn1 Na+/HCO3− cotransporter catalyzes the electroneutral movement of 1 Na+:1 HCO3− into kidney cells. We characterized the intracellular pH (pHi) regulation in human embryonic kidney cells (HEK) subjected to NH4Cl ...
Mechanisms underlying the toxic effects of antimony species in human embryonic kidney cells (HEK-293) and their comparison with arsenic species
(2016)
Antimony cytotoxicity was assessed in human embryonic kidney cells (HEK-293). Uptake, mitochondrial respiratory activity, ROS generation and diffusional kinetics were measured using fluorescence recovery after photobleaching ...
Effect of Protein Denaturation and Enzyme Inhibitors on Proteasomal-Mediated Production of Peptides in Human Embryonic Kidney Cells
(Mdpi, 2019-06-01)
Peptides produced by the proteasome have been proposed to function as signaling molecules that regulate a number of biological processes. In the current study, we used quantitative peptidomics to test whether conditions ...
Nicotinic receptor M3 transmembrane domain: Position 8′ contributes to channel gating
(American Society for Pharmacology and Experimental Therapeutics, 2002-08-01)
The nicotinic acetylcholine receptor (nAChR) is a pentamer of homologous subunits with composition α2βεδ in adult muscle. Each subunit contains four transmembrane domains (M1-M4). Position 8′ of the M3 domain is phenylalanine ...