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Hsp90-binding immunophilin FKBP51 forms complexes with hTERT enhancing telomerase activity
(Elsevier, 2016-05-17)
FK506-binding proteins are members of the immunophilin family of proteins. Those immunophilins associated to the 90-kDa-heat-shock protein, Hsp90, have been proposed as potential modulators of signalling cascade factors ...
Study of hTERT and Histone 3 Mutations in Medulloblastoma
(Karger, 2017)
Hotspot activating mutations of the telomerase reverse transcriptase (hTERT) promoter region were recently described in several tumor types. These mutations lead to enhanced expression of telomerase, being responsible for ...
hTERT and TP53 deregulation in intestinal-type gastric carcinogenesis in non-human primates
(Springer, 2013-08-01)
Despite the high incidence, the molecular events involved in intestinal-type gastric carcinogenesis remains unclear. We previously established an intestinal-type gastric carcinogenesis model in Cebus apella, a New World ...
Effect of several PEO-PPO amphiphiles on bax, bcl-2, and hTERT mRNAs: An insight into apoptosis and cell immortalization induced in hepatoma cells by these polymeric excipients
(Wiley, 2016-03)
Recent data have shown that synthetic polymers and nanomaterials display phenotypic effects in cells and signal transduction mechanisms involved in inflammation, differentiation, proliferation, and apoptosis. Aim: This ...
Regulação epigenética dos genes SIRT3, SMARCA5, HTERT e CDH1 no envelhecimento e na doença de Alzheimer
(Universidade Federal de São Paulo (UNIFESP), 2007)
Objetivos: Este estudo teve como objetivo avaliar a regulação epigenética do DNA pelas freqüências de metilação das regiões promotoras dos genes SIRT3, SMARCA5, HTERT e CDH1, envolvidos na longevidade, diferenciação ...
hTERT, MYC and TP53 deregulation in gastric preneoplastic lesions
(Biomed Central Ltd, 2012-07-06)
Background: Gastric cancer is a serious public health problem in Northern Brazil and in the world due to its high incidence and mortality. Despite the severity of the disease, more research is needed to better understand ...
Immunohistochemical expression of p53, p16 and hTERT in oral squamous cell carcinoma and potentially malignant disorders
(Sociedade Brasileira de Pesquisa Odontológica, 2011)
Oral carcinogenesis is a multi-step process. One possible step is the development of potentially malignant disorders known as leukoplakia and erytroplakia. The objective of this study was to use immunohistochemistry to ...
Acción biológica de la inmunofilina de alto peso molecular FKBP51 en procesos malignos
(2017-11-27)
Las inmunofilinas son proteínas con actividad enzimática de peptidilprolyl-isomerasa que unen drogas inmunosupresoras. La inmunofilina FKBP51 forma complejos con la chaperona HSP90 y une al macrólido FK506. En este trabajo, ...