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Differential RNA sequence requirement for dengue virus replication in mosquito and mammalian cells
(American Society for Microbiology, 2013-08)
Dengue virus cycles between mosquitoes and humans. Each host provides a different environment for viral replication, imposing different selective pressures. We identified a sequence in the dengue virus genome that is ...
RNA Structure Duplications and Flavivirus Host Adaptation
(Elsevier Science London, 2016-02)
Flaviviruses include a highly diverse group of arboviruses with a global distribution and a high human disease burden. Most flaviviruses cycle between insects and vertebrate hosts; thus, they are obligated to use different ...
RNA Structure Duplication in the Dengue Virus 3′ UTR: Redundancy or Host Specificity?
(American Society for Microbiology, 2019-01)
Flaviviruses include a diverse group of medically important viruses that cycle between mosquitoes and humans. During this natural process of switching hosts, each species imposes different selective forces on the viral ...
ExplorATE: A new pipeline to explore active transposable elements from RNA-seq data
(Oxford University Press, 2022-07)
Motivation: Transposable elements (TEs) are ubiquitous in genomes and many remain active. TEs comprise an important fraction of the transcriptomes with potential effects on the host genome, either by generating deleterious ...
Zika Virus Subgenomic Flavivirus RNA Generation Requires Cooperativity between Duplicated RNA Structures That Are Essential for Productive Infection in Human Cells
(American Society for Microbiology, 2020-08)
Zika virus (ZIKV) is an emerging flavivirus, mainly transmitted by mosquitoes, which represents a global health threat. A common feature of flavivirus-infected cells is the accumulation of viral noncoding subgenomic RNAs ...
Uncoupling cis-Acting RNA elements from coding sequences revealed a requirement of the N-terminal region of dengue virus capsid protein in virus particle formation
(American Society For Microbiology, 2012-01)
Little is known about the mechanism of flavivirus genome encapsidation. Here, functional elements of the dengue virus (DENV) capsid (C) protein were investigated. Study of the N-terminal region of DENV C has been limited ...
Evolution and Application of Inteins in Candida species: A Review
(Frontiers Media Sa, 2016-10-10)
Inteins are invasive intervening sequences that perform an autocatalytic splicing from their host proteins. Among eukaryotes, these elements are present in many fungal species, including those considered opportunistic or ...
Estudio de los genomas virales defectuosos en la línea celular c6l-60 persistentemente infectada con el virus de dengue 2
(2012-03-06)
RESUMEN: El Dengue es un virus de una sola cadena de RNA que pertenece a la familia Flaviviridae género flavivirus de aproximadamente 40 a 50 nm de diámetro del cual existen 4 serotipos (DEN1-4) y es el agente causal de ...