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Chaperone mediated autophagy contributes to the newly synthesized histones H3 and H4 quality control
(2022)
Although there are several pathways to ensure that proteins are folded properly in the cell, little is known about the molecular mechanisms regulating histone folding and proteostasis. In this work, we identified that ...
HAG3, a Histone Acetyltransferase, Affects UV-B Responses by Negatively Regulating the Expression of DNA Repair Enzymes and Sunscreen Content in Arabidopsis thaliana
(Oxford University Press, 2015-04)
Histone acetylation is regulated by histone acetyltransferases and deacetylases. In Arabidopsis, there are 12 histone acetyltransferases and 18 deacetylases. Histone acetyltransferases are organized in four families: ...
Epigenetic regulatory mechanisms induced by resveratrol
(2017-11-01)
Resveratrol (RVT) is one of the main natural compounds studied worldwide due to its potential therapeutic use in the treatment of many diseases, including cancer, diabetes, cardiovascular diseases, neurodegenerative diseases ...
HAC1 and HAF1 histone acetyltransferases have different roles in UV-B responses in arabidopsis
(Frontiers Research Foundation, 2017-07)
Arabidopsis has 12 histone acetyltransferases grouped in four families: the GNAT/HAG, the MYST/HAM, the p300/CBP/HAC and the TAFII250/HAF families. We previously showed that ham1 and ham2 mutants accumulated higher damaged ...
Differential expression of histone deacetylase and acetyltransferase genes in gastric cancer and their modulation by trichostatin A
(Springer, 2014-07-01)
Gastric cancer is still the second leading cause of cancer-related death worldwide, even though its incidence and mortality have declined over the recent few decades. Epigenetic control using histone deacetylase inhibitors, ...