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Optimization of (–)-cubebin biotransformation to (–)-hinokinin by the marine fungus Absidia coerulea 3A9
(2021-09-01)
The genus Absidia is widely used in the biotransformation of different classes of natural products. This study evaluates the ability of the Absidia coerulea 3A9 marine derived strain isolated from the ascidian Distaplia ...
(-)-Hinokinin-loaded poly(d,l-lactide-co-glycolide) microparticles for Chagas disease
(Springer, 2010-02-01)
The (-)-hinokinin display high activity against Trypanosoma cruzi in vitro and in vivo. (-)-Hinokinin-loaded poly(d,l-lactide-co-glycolide) microparticles were prepared and characterized in order to protect (-)-hinokinin ...
(-)-Hinokinin-loaded poly(d,l-lactide-co-glycolide) microparticles for Chagas disease
(Springer, 2010-02-01)
The (-)-hinokinin display high activity against Trypanosoma cruzi in vitro and in vivo. (-)-Hinokinin-loaded poly(d,l-lactide-co-glycolide) microparticles were prepared and characterized in order to protect (-)-hinokinin ...
Synthesis of (-)-hinokinin by oxidation of (-)-cubebin catalyzed by biomimetic metalloporphyrin catalytic systems
(ELSEVIER SCIENCE BV, 2009)
A catalytic system consisting of iron tetraphenylporphyrin supported on an alumina matrix for oxidation of (-)-cubebin with iodosylbenzene or hydrogen peroxide is reported. Conversion of (-)-cubebin is very efficient (100%) ...
Effect of the dibenzylbutyrolactone lignan (-)-hinokinin on doxorubicin and methyl methanesulfonate clastogenicity in V79 Chinese hamster lung fibroblasts
(Elsevier B.V., 2010-07-19)
The dibenzylbutyrolactone lignan (-)-hinokinin (HK) was obtained by partial synthesis from (-)-cubebin, isolated from the dry seeds of the pepper, Piper cubeba. In view of the trypanocidal activity of HK and its potential ...
Mutagenicity and antimutagenicity of (-)-hinokinin a trypanosomicidal compound measured by Salmonella microsome and comet assays
(Biomed Central Ltd., 2012-10-31)
Background: The dibenzylbutyrolactone lignan (-)-hinokinin (HK) was derived by partial synthesis from (-)- cubebin, isolated from the dry seeds of the pepper, Piper cubeba. Considering the good trypanosomicidal activity ...
Mutagenicity and antimutagenicity of (-)-hinokinin a trypanosomicidal compound measured by Salmonella microsome and comet assays
(Biomed Central Ltd., 2012-10-31)
Background: The dibenzylbutyrolactone lignan (-)-hinokinin (HK) was derived by partial synthesis from (-)- cubebin, isolated from the dry seeds of the pepper, Piper cubeba. Considering the good trypanosomicidal activity ...
Effect of the dibenzylbutyrolactone lignan (-)-hinokinin on doxorubicin and methyl methanesulfonate clastogenicity in V79 Chinese hamster lung fibroblasts
(Elsevier B.V., 2010-07-19)
The dibenzylbutyrolactone lignan (-)-hinokinin (HK) was obtained by partial synthesis from (-)-cubebin, isolated from the dry seeds of the pepper, Piper cubeba. In view of the trypanocidal activity of HK and its potential ...
In vivo and in silico anti-inflammatory mechanism of action of the semisynthetic (−)-cubebin derivatives (−)-hinokinin and (−)-O-benzylcubebin
(2017-01-01)
(−)-Cubebin (CUB), isolated from seeds of Piper cubeba, was used as starting material to obtain the derivatives (−)-hinokinin (HK) and (−)-O-benzyl cubebin (OBZ). Using paw edema as the experimental model and different ...
(-)-Hinokinin-loaded poly(d,l-lactide-co-glycolide) microparticles for Chagas disease
(SPRINGER, 2010)
The (-)-hinokinin display high activity against Trypanosoma cruzi in vitro and in vivo. (-)-Hinokinin-loaded poly(d,l-lactide-co-glycolide) microparticles were prepared and characterized in order to protect (-)-hinokinin ...