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Estudo da participação dos receptores histaminérgicos centrais dos tipos H1 e H2 no controle da ingestão de água
(Centro de Pesquisas Gonçalo Moniz, 2019)
Hyaluronan as drug carrier. The in vitro efficacy and selectivity of Hyaluronan-Doxorubicin complexes to affect the viability of overexpressing CD44 receptor cells
(Elsevier Science, 2014-09)
We report Doxorubicin ionic complexes with hyaluronic acid (HiH-Dx) or its sodium salt (HiNa-Dx) as tumor-targeting delivery system. The complexes were prepared in situ by mixing aqueous solutions of Dx.HCl with HiH or ...
Reversion by Vitamin E treatment of the oxidative damage but not of the advancement in reproductive senescence produced by neonatal hypoxia or hypoxia-ischemia in female rats
(Karger, 2014-07)
Background/Aims: Few studies address the long-term consequences of perinatal hypoxia, a frequent birth complication. Previously we described advanced reproductive senescence (premature loss of regular cyclicity) in female ...
PI3K pathway is involved in ERK signaling cascade activation by histamine H2R agonist in HEK293T cells
(Elsevier Science, 2016-06-15)
Histamine, through histamine H2 receptor (H2R), modulates different biological processes, involving the modulation of PI3K/AKT/mTOR and RAS/RAF/MEK/ERK pathways. Many evidences have demonstrated the existence and importance ...
The effect of angiotensin II on intracellular pH is mediated by AT(1) receptor translocation
(AMER PHYSIOLOGICAL SOC, 2008)
The effect of ANG II on intracellular pH (pH(i)) recovery rate and AT(1) receptor translocation was investigated in transfected MDCK cells. The pHi recovery rate was evaluated by fluorescence microscopy using the fluorescent ...
Inhibition of mammary tumor growth by estrogens: Is there a specific role for estrogen receptors alpha and beta?
(Springer, 2010-10)
To evaluate the extent to which each estrogen receptor (ER) subtype contributes to the stimulation or to the inhibition of mammary tumor growth, we evaluated the effects of specific agonists in MC4-L2 cells, which are ...
Estudo do envolvimento das vias histaminérgicas no controle da ingestão de água e sal em ratos
(Centro de Pesquisas Gonçalo Moniz, 2007)
Os diferentes mecanismos cerebrais de controle do comportamneto de ingestão hídrica desencadeado pela sede, bem como o apetite específico por sódio têm sido objetos de investigação de diversos grupos de pesquisas. A ...
Reversion by Vitamin E Treatment of the Oxidative Damage but Not of the Advancement in Reproductive Senescence Produced by Neonatal Hypoxia or Hypoxia-Ischemia in Female Rats
(Karger, 2014)
BACKGROUND/AIMS:
Few studies address the long-term consequences of perinatal hypoxia (H), a frequent birth complication. Previously we described advanced reproductive senescence (premature loss of regular cyclicity) in ...
Reversion by Vitamin E Treatment of the Oxidative Damage but Not of the Advancement in Reproductive Senescence Produced by Neonatal Hypoxia or Hypoxia-Ischemia in Female Rats
(Karger, 2014)
BACKGROUND/AIMS:
Few studies address the long-term consequences of perinatal hypoxia (H), a frequent birth complication. Previously we described advanced reproductive senescence (premature loss of regular cyclicity) in ...