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Herpud1 impacts insulin-dependent glucose uptake in skeletal muscle cells by controlling the Ca2+-calcineurin-Akt axis
(Elsevier B.V., 2018)
© 2018 Elsevier B.V. Skeletal muscle plays a central role in insulin-controlled glucose homeostasis. The molecular mechanisms related to insulin resistance in this tissue are incompletely understood. Herpud1 is an endoplasmic ...
A new role for HERPUD1 and ERAD activation in osteoblast differentiation and mineralization
Bone integrity depends on a finely tuned balance between bone synthesis by osteoblasts and resorption by osteoclasts. The secretion capacity of mature osteoblasts requires strict control of proteostasis. Endoplasmic ...
Herpud1 negatively regulates pathological cardiac hypertrophy by inducing IP3 receptor degradation
(Nature Publishing Group, 2017)
Cardiac hypertrophy is an adaptive response triggered by pathological stimuli. Regulation of the synthesis and the degradation of the Ca2+ channel inositol 1,4,5-trisphosphate receptor (IP3R) affects progression to cardiac ...
HERPUD1 protects against oxidative stress-induced apoptosis through downregulation of the inositol 1,4,5-trisphosphate receptor
(Elsevier, 2016)
Homocysteine-inducible, endoplasmic reticulum (ER) stress-inducible, ubiquitin-like domain member 1 (HERPUD1), an ER resident protein, is upregulated in response to ER stress and Ca2(+) homeostasis deregulation. HERPUD1 ...
Expression of Herpud1 during osteoclast and osteoblast differentiation
Bone is a dynamic tissue characterized by its hardness, rigidity, and high power of regeneration and repair. Its integrity is the result of balance among synthesis mediated by osteoblasts and resorption mediated by osteoclast ...
Expression of Herpud1 during osteoclast and osteoblast differentiation
(FEDERATION AMER SOC EXP BIOL, 2016)
HERPUD1 protects against oxidative stress-induced apoptosis through downregulation of the inositol 1,4,5-trisphosphate receptor
(2016)
Homocysteine-inducible, endoplasmic reticulum (ER) stress-inducible, ubiquitin-like domain member 1 (HERPUD1), an ER resident protein, is upregulated in response to ER stress and Ca(2+) homeostasis deregulation. HERPUD1 ...