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Dynamic Localization of Hepatocellular Transporters: Role in Biliary Excretion and Impairment in Cholestasis
(Bentham Science Publishers, 2017-12)
Bile acids, synthesized by hepatocytes from cholesterol, are specific and quantitatively important organic components of bile, where they are the main driving force of the osmotic process that generates bile flow toward ...
Ursodeoxycholic acid in cholestasis: linking action mechanisms to therapeutic applications
(Portland Press, 2011-12)
UDCA (ursodeoxycholic acid) is the therapeutic agent most widely used for the treatment of cholestatic hepatopathies. Its use has expanded to other kinds of hepatic diseases, and even to extrahepatic ones. Such versatility ...
Physiological concentrations of unconjugated bilirubin prevent oxidative stress‑induced hepatocanalicular dysfunction and cholestasis
(Springer, 2014-11)
Bilirubin is an endogenous antioxidant with cytoprotective properties, and several studies highlight its potential in the treatment of pro-oxidant diseases. We demonstrated that oxidative stress (OS), a key feature in most ...
Anticholestatic mechanisms of ursodeoxycholic acid in lipopolysaccharide-induced cholestasis
(Pergamon-Elsevier Science Ltd, 2019-10)
Lipopolysaccharide (LPS) from Gram (-) bacteria induces inflammatory cholestasis by impairing the expression/localization of transporters involved in bile formation (e.g., Bsep, Mrp2). Therapeutic options for this disease ...
Mitogen-activated protein kinases are involved in hepatocanalicular dysfunction and cholestasis induced by oxidative stress
(Springer, 2017-06)
In previous studies, we showed that the pro-oxidant model agent tert-butyl hydroperoxide (tBuOOH) induces alterations in hepatocanalicular secretory function by activating Ca2+-dependent protein kinase C isoforms (cPKC), ...
Spironolactone ameliorates lipopolysaccharide-induced cholestasis in rats by improving Mrp2 function: Role of transcriptional and post-transcriptional mechanisms
(Pergamon-Elsevier Science Ltd, 2020-10)
Aims: Lipopolysaccharide (LPS) induces inflammatory cholestasis by impairing expression, localization, and function of carriers involved in bile formation, e.g. bile salt export pump (Bsep) and multidrug resistance-associated ...
ENHANCED BILIARY-EXCRETION OF CANALICULAR MEMBRANE ENZYMES IN ESTROGEN-INDUCED AND OBSTRUCTIVE CHOLESTASIS, AND EFFECTS OF DIFFERENT BILE-ACIDS IN THE ISOLATED-PERFUSED RAT-LIVER
(MUNKSGAARD INT PUBL LTD, 1995)
Backgrounds/Aims: Canalicular membrane enzymes are normally released into bile by partially known processes. This study was undertaken to investigate whether hepatocellular cholestasis induced in rats by ethynylestradiol ...