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Risks, Benefits, and Therapeutic Potential of Hematopoietic Stem Cell Transplantation for Autoimmune Diabetes
(CURRENT MEDICINE GROUPPHILADELPHIA, 2012)
Type 1 diabetes mellitus is a chronic disease that results from the autoimmune response against pancreatic insulin producing beta cells. Apart of several insulin regimens, since the decade of 80s various immunomodulatory ...
Hematopoietic Stem Cells but Not Multipotent Progenitors Drive Erythropoiesis during Chronic Erythroid Stress in EPO Transgenic Mice
(Elsevier, 2018)
The hematopoietic stem cell (HSC) compartment consists of a small pool of cells capable of replenishing all blood cells. Although it is established that the hematopoietic system is assembled as a hierarchical organization ...
Decitabine maintains hematopoietic precursor self-renewal by preventing repression of stem cell genes by a differentiation-inducing stimulus
(American Association for Cancer Research, 2010-06)
The cytosine analogue decitabine alters hematopoietic differentiation. For example, decitabine treatment increases self-renewal of normal hematopoietic stem cells. The mechanisms underlying decitabine-induced shifts in ...
Obesity and inflammation and the effect on the hematopoietic system
(Associação Brasileira de Hematologia e Hemoterapia e daSociedade Brasileira de Transplante de Medula Óssea, 2014)
Autologous hematopoietic stem cell transplantation for autoimmune diseases: From mechanistic insights to biomarkers
(2018-11-16)
Phase I/II clinical trials of autologous hematopoietic stem cell transplantation (AHSCT) have led to increased safety and efficacy of this therapy for severe and refractory autoimmune diseases (AD). Recent phase III ...
Factors affecting hematopoietic progenitor cell mobilization: An analysis of 307 patients
(PERGAMON-ELSEVIER SCIENCE LTD, 2008)
We reviewed the data of 307 patients treated with autologous bone marrow transplantation with the aim to identify factors associated with poor hematopoietic stern cell (HSC) mobilization after administration of cyclophosphamide ...
SEROLOGICAL MONITORING OF A Toxoplasma INFECTION AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION
(Inst Medicina Tropical Sao PauloSao PauloBrasil, 2010)
Hematopoietic SCT modulates gut inflammation in experimental inflammatory bowel disease
(NATURE PUBLISHING GROUP, 2010)
Hematopoietic SCT (HSCT) and high-dose chemotherapy are being explored as therapy for various human refractory immune-mediated conditions, including inflammatory bowel diseases (IBD). Nevertheless, the exact immunological ...