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Study of capillary network directionality and irrigation of hypoxic tissue in an angiogenesis lattice model
(Elsevier Science, 2013-08)
To shed light on the understanding of the angiogenesis process, we study a simplified lattice model for the capillary network formation between an existing blood vessel and an initially hypoxic tissue. We consider that the ...
Recapitulation of Hypoxic Tumor–stroma Microenvironment to Study Photodynamic Therapy Implications
(Wiley Blackwell Publishing, Inc, 2020-07)
Tumor microenvironment (TME) is a dynamic ecosystem where fibroblasts are recruited in order to provide a niche to support growth and, in some extent, to promote therapeutic resistance. However, the role of fibroblasts in ...
Glycosidic carbonic anhydrase IX inhibitors: a sweet approach against cancer
(Elsevier, 2013-03)
Targeting tumour associated carbonic anhydrase (CA, EC 4.2.1.1) isoforms IX and XII is now considered as a pertinent approach for the development of new cancer therapeutics against hypoxic tumours. In the last period, with ...
Metabolic coupling in urothelial bladder cancer compartments and its correlation to tumor aggressiveness
(Taylor & Francis Inc, 2016-02-01)
Monocarboxylate transporters (MCTs) are vital for intracellular pH homeostasis by extruding lactate from highly glycolytic cells. These molecules are key players of the metabolic reprogramming of cancer cells, and evidence ...
Hypoxic Melanoma Cells Deliver microRNAs to Dendritic Cells and Cytotoxic T Lymphocytes through Connexin-43 Channels
(MDPI, 2020)
Alterations in microRNA (miRNA) profiles, induced by tumor microenvironment stressors, like hypoxia, allow cancer cells to acquire immune-resistance phenotypes. Indeed, hypoxia-induced miRNAs have been implicated in cancer ...
The Carbonic Anhydrase Inhibitor E7070 Sensitizes Glioblastoma Cells to Radio- and Chemotherapy and Reduces Tumor Growth
(2021-01-01)
Glioblastomas (GBMs), the most common and lethal primary brain tumor, show inherent infiltrative nature and high molecular heterogeneity that make complete surgical resection unfeasible and unresponsive to conventional ...
Hypoxic and reoxygenated microenvironment: stemness and differentiation state in glioblastoma
(Springer, 2016-10)
Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor in adults. Hypoxia is a distinct feature in GBM and plays a significant role in tumor progression, resistance to treatment, and poor outcome. ...