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Bang-bang control of feeding: role of hypothalamic and satiety signals
(Public Library of Science, 2007)
Rats, people, and many other omnivores eat in meals rather than continuously. We show by experimental test that eating in meals is regulated by a simple bang-bang control system, an idea foreshadowed by Le Magnen and many ...
Effect of hyperthyroidism on circulating prolactin and hypothalamic expression of tyrosine hydroxylase, prolactin signaling cascade members and estrogen and progesterone receptors during late pregnancy and lactation in the rat
(Elsevier Ireland, 2017-02)
Hyperthyroidism (HyperT) compromises pregnancy and lactation, hindering suckling-induced PRL release. We studied the effect of HyperT on hypothalamic mRNA (RT-qPCR) and protein (Western blot) expression of tyrosine hydroxylase ...
Estradiol-mediated axogenesis of hypothalamic neurons requires ERK1/2 and ryanodine receptors-dependent intracellular Ca2+ rise in male rats
(Frontiers Media S.A., 2019-01)
17β-estradiol (E2) induces axonal growth through extracellular signal-regulated kinase 1 and 2 (ERK1/2)-MAPK cascade in hypothalamic neurons of male rat embryos in vitro, but the mechanism that initiates these events is ...
Low-Grade Hypothalamic Inflammation Leads to Defective Thermogenesis, Insulin Resistance, and Impaired Insulin Secretion
(Endocrine SocChevy ChaseEUA, 2011)
Acute physical exercise increases leptin-induced hypothalamic extracellular signal-regulated kinase1/2 phosphorylation and thermogenesis of obese mice
(2018-01-01)
The obesity is a result of energy imbalance and the increase in thermogenesis seems an interesting alternative for the treatment of this disease. The mechanism of energy expenditure through thermogenesis is tightly articulated ...
Emerging insights into hypothalamic-pituitary- gonadal axis regulation and interaction with stress signalling.
(Comité editorial Journal of Neuroendocrinology, 2018-10-30)
ARTÍCULO PUBLICADO EN REVISTA EXTERNA.Reproduction and fertility are regulated via hormones of the hypothalamic-pituitary-gonadal (HPG) axis. Control of this reproductive axis occurs at all levels, including the brain and ...
Hypothalamic GLUT2 inhibition impacts the feeding behavior
(2017)
Glucose is a key modulator of feeding behavior both at peripheral
tissues and the central nervous system, where it is known to
modify neuropeptide expression involved in hunger/satiety signals.
In the brain, glucose sensing ...
Hypothalamic Inhibition of Acetyl-CoA Carboxylase Stimulates Hepatic Counter-Regulatory Response Independent of AMPK Activation in Rats
(Public Library ScienceSan FranciscoEUA, 2013)