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Expression of hMLH1 and hMSH2 proteins in ameloblastomas and tooth germs
(Medicina Oral S.L., 2018)
A change of view: Homologous recombination at single-molecule resolution
(Nature Publishing Group, 2018-04)
Genetic recombination occurs in all organisms and is vital for genome stability. Indeed, in humans, aberrant recombination can lead to diseases such as cancer. Our understanding of homologous recombination is built upon ...
From fish to modern humans - comparative anatomy, homologies and evolution of the pectoral and forelimb musculature
(Wiley Blackwell Publishing, Inc, 2009-12)
In a recent paper Diogo and Abdala reported the results of the first part of a research project on the comparative anatomy, homologies and evolution of the pectoral muscles of osteichthyans (bony fish + tetrapods). That ...
Expanding the horizons of G protein-coupled receptor structure-based ligand discovery and optimization using homology models
(Royal Society of Chemistry, 2015-07)
With >800 members in humans, the G protein-coupled receptor (GPCR) super-family is the target for more than 30% of the marketed drugs. The recent boom in GPCR crystallography has enabled the solution of ∼30 different GPCR ...
Non-homologous end joining is the responsible pathway for the repair of fludarabine-induced DNA double strand breaks in mammalian cells
(Elsevier Science, 2008-11)
Fludarabine (FLU), an analogue of adenosine, interferes with DNA synthesis and inhibits the chain elongation leading to replication arrest and DNA double strand break (DSB) formation. Mammalian cells use two main pathways ...
Differential contribution of HP1 proteins to DNA end resection and homology-directed repair
(Taylor & Francis, 2013-02)
Heterochromatin protein 1 paralogs (HP1α, β and γ in mammals) are not only central in heterochromatin organization, but have also been linked to transcriptional activation at euchromatic regions, maintenance of telomere ...
Improved orthologous databases to ease protozoan targets inference
(BioMed Central, 2016)
The Knowns Unknowns: Exploring the Homologous Recombination Repair Pathway in Toxoplasma gondii
(Frontiers in Bioscience, 2016-05)
Toxoplasma gondii is an apicomplexan parasite of medical and veterinary importance which causes Toxoplasmosis in humans. Great effort is currently being devoted towards the identification of novel drugs capable of targeting ...