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QSAR and molecular graphics analysis of N-2-phenylguanines as inhibitors of herpes simplex virus thymidine kinases
(Elsevier Science IncNew YorkEUA, 2000)
Prediction of the binding mode of N-2-phenylguanine derivative inhibitors to herpes simplex virus type 1 thymidine kinase
(Kluwer Academic PublDordrechtHolanda, 1998)
Suicide gene therapy on spontaneous canine melanoma: correlations between in vivo tumors and their derived multicell spheroids in vitro
(Nature Publishing Group, 2010-01)
To validate the use of multicellular spheroids to predict the efficacy of herpes simplex thymidine kinase/ganciclovir (HSVtk/GCV) suicide gene therapy in the respective in vivo tumors, we established and characterized 15 ...
The combination of bleomycin with suicide or interferon-B gene transfer is able to efficiently eliminate human melanoma tumor initiating cells
(Elsevier France-editions Scientifiques Medicales Elsevier, 2016-10)
We explored the potential of a chemogene therapy combination to eradicate melanoma tumor initiating cells, key producers of recurrence and metastatic spread. Three new human melanoma cell lines, two obtained from lymph ...
Mechanisms enhancing the cytotoxic effects of bleomycin plus suicide or interferon-β gene lipofection in metastatic human melanoma cells
(Bentham Science Publishers, 2018-05)
Background: Three metastatic human melanoma cell lines generated from patient removed lymph nodes and spleen metastasis were established in our laboratory. Objective: To investigate the mechanisms enhancing the cytotoxic ...
Herpes simples: patogênese, diagnóstico e tratamento atual com agentes antivirais.
(Universidade Federal do Rio Grande do NorteBrasilUFRNFarmácia, 2019-08-05)
Herpes, disease caused by herpes virus 1 (HSV-1) and 2 (HSV-2) is the most common sexually transmitted infection in the world. Herpesvirus simplex 1 (HSV-1) and 2 (HSV-2) are DNA virus belonging to Herpesviridae family. ...
Proliferation index and pseudoprogression as predictors of the therapeutic efficacy of suicide gene therapy for canine melanoma
(Lippincott Williams, 2018-12)
In our veterinary clinical trials, the combination of systemic immunotherapy with local HSVtk/GCV suicide gene (SG) treatment induced tumor pseudo-progression as part of a strong local anti-tumor response. This phenomenon ...
Therapeutic potential of bleomycin plus suicide or interferon-β gene transfer combination for spontaneous feline and canine melanoma
(Impact Journals, 2017-12)
We originated and characterized melanoma cell lines derived from tumors of two feline and two canine veterinary patients. These lines reestablished the morphology, physiology and cell heterogeneity of their respective ...
Modelagem molecular da timidina quinase: um importante alvo terapêutico no Vírus Herpes Simplex e avaliação da resistência
(Universidade Federal do Rio de JaneiroBrasilInstituto de Ciências FarmacêuticasUFRJ, 2023)