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Protozoan HSP90-heterocomplex: molecular interaction network and biological significance
(Bentham Science Publishers, 2014-05)
The HSP90 chaperone is a highly conserved protein from bacteria to higher eukaryotes. In eukaryotes, this chaperone participates in different large complexes, such as the HSP90 heterocomplex, which has important biological ...
Role of hsp90 and the hsp90-binding immunophilins in signalling protein movement
(Elsevier Inc, 2004)
The ubiquitous protein chaperone hsp90 has been shown to regulate more than 100 proteins involved in cellular signalling. These proteins are called 'client proteins' for hsp90, and a multiprotein hsp90/hsp70-based chaperone ...
The hsp90-FKBP52 complex links the mineralocorticoid receptor to motor proteins and persists bound to the receptor in early nuclear events
(American Society for Microbiology, 2010-03)
In this study, we demonstrate that the subcellular localization of the mineralocorticoid receptor (MR) is regulated by tetratricopeptide domain (TPR) proteins. The high-molecular-weight immunophilin (IMM) FKBP52 links the ...
Reconstitution of the steroid receptor heterocomplex
(Humana Press, 2019-03)
Steroid receptors are members of a subfamily of the nuclear receptor superfamily. They play a dual role of steroid hormone receptors and transcription factors. Actually, these receptors are steroid-activated transcription ...
Role of the Hsp90-immunophilin heterocomplex in cancer disease
(Bentham Science Publishers, 2019)
The identification of new factors that may function as cancer markers and becomeeventual pharmacologic targets is a challenge that may influence the management of tumor developmentand management. Recent discoveries connecting ...
Nuclear Import of the Glucocorticoid Receptor-hsp90 Complex through the Nuclear Pore Complex Is Mediated by Its Interaction with Nup62 and Importin β
(American Society for Microbiology, 2009-09)
Glucocorticoid receptor (GR) is cytoplasmic in the absence of ligand and localizes to the nucleus after steroid binding. Previous evidence demonstrated that the hsp90-based heterocomplex bound to GR is required for the ...
Subcellular rearrangement of Hsp90-binding immunophilins accompanies neuronal differentiation and neurite outgrowth
(Wiley, 2010-11)
FKBP51 and FKBP52 (FK506-binding protein 51 and 52) are tetratricopeptide repeat-domain immunophilins belonging to the tetratricopeptide-protein•hsp90•hsp70•p23 heterocomplex bound to steroid receptors. Immunophilins are ...
Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus
(American Society for Biochemistry and Molecular Biology, 2004)
The tumor suppressor protein p53 is known to be transported to the nucleus along microtubular tracks by cytoplasmic dynein. However, the connection between p53 and the dynein motor protein complex has not been established. ...
Evidence for glucocorticoid receptor transport on microtubules by dynein
(American Society for Biochemistry and Molecular Biology, 2004)
Rapid, ligand-dependent movement of glucocorticoid receptors (GR) from cytoplasm to the nucleus is hsp90-dependent, and much of the movement system has been defined. GR.hsp90 heterocomplexes isolated from cells contain one ...
Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation
(American Society for Biochemistry and Molecular Biology, 2004)
Pifithrin-alpha (PFTalpha) was originally thought to be a specific inhibitor of signaling by the tumor suppressor protein p53. However, the laboratory that discovered pifithrin recently reported that the compound also ...