Buscar
Mostrando ítems 1-10 de 194
Chemometrics-assisted multi-instrumental techniques for investigation of interactions of dapagliflozin with normal and glycated human serum albumin: application to exploiting second-order advantage for determination of glycated human serum albumin as a biomarker for controlling diabetes
(Elsevier Science, 2021-08)
In this paper, we have collected useful information about interactions of dapagliflozin (DPA) with normal human serum albumin (HSA) and glycated HSA (GHSA) by using spectroscopic and electrochemical methods. Instrumental ...
Influência do grupo carboxílico na atividade citotóxica e na interação de novos complexos de rutênio com DNA e HSA
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Química - PPGQCâmpus São Carlos, 2016-02-25)
The purpose of this work is evaluate how the position of a free carboxyl group can affect the interaction with DNA and HSA, and the cytotoxic profile against tumor and normal cells and Mycobacterium tuberculosis, for a set ...
Investigação das propriedades fotofísicas de porfirinas meso substituídas com complexos de RuII e estudo da interação com biomoléculas
(Universidade Federal de Santa MariaBrasilQuímicaUFSMPrograma de Pós-Graduação em QuímicaCentro de Ciências Naturais e Exatas, 2019-08-05)
The objective of this work was to investigate the photophysical properties of two porphyrins whose syntheses are already reported in the literature: meso-tetra(4-pyridyl)porphyrin tetra-ruthenated free-base (H2RuTPyP) and ...
O efeito do pH na interação da albumina sérica humana e os flavonoides quercetina e quercitrina
(Universidade Estadual Paulista (Unesp), 2014-05-30)
The flavonoids are poliphenolic compounds found in plants, which are responsible to provide pigmentation and in some cases act as an inhibitors of infections mediated by microorganism. Recently, their role as an antioxidant ...
Interactions between DMPC Liposomes and the Serum Blood Proteins HSA and IgG
(American Chemical Society, 2009-02)
The interaction between two serum blood proteins, namely human serum albumin (HSA) and human immunoglobulin G (IgG), with 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine (DMPC) liposomes has been studied in detail using ...
Investigation on the interaction between nanocarriers and functional compounds of flavonoids
(2018-04-25)
Studies have suggested that a diet rich in functional foods containing flavonoids provides benefits to human health for anti-inflammatory, antioxidant, antibacterial, and anticancer activities. These compounds are usually ...
Avaliação das propriedades de interação envolvendo as proteínas Albumina de Soro Humano (HSA) e Albumina de Soro Bovino (BSA).
(Universidade Estadual Paulista (Unesp), 2021-02-04)
Albumina de Soro Humano (HSA) é uma proteína com grande importância biológica especialmente por sua função transportadora. Alterações em suas características de transporte é um problema chave em estudos atuais. O estresse ...
Estudo da interação de cumarinas e proteína envolvida na doença inflamatória intestinal por ressonância magnética nuclear
(Universidade Estadual Paulista (Unesp), 2017-05-29)
A Doença Inflamatória Intestinal (DII) é um conjunto de desordens inflamatórias, crônica e, até o momento, sem cura do trato gastrointestinal. Engloba principalmente a doença de Cohn e a retocolite ulcerativa, que podem ...
Oxidative alteration of Trp-214 and Lys-199 in human serum albumin increases binding affinity with phenylbutazone: A combined experimental and computational investigation
(2018-10-01)
Human serum albumin (HSA) is a target for reactive oxygen species (ROS), and alterations of its physiological functions caused by oxidation is a current issue. In this work, the amino-acid residues Trp-214 and Lys-199, ...